SML4233

Perampanel

≥98% (HPLC)

• Synonym(e): 2-(1′,6′-Dihydro-6′-oxo-1′-phenyl[2,3′-bipyridin]-5′-yl)-benzonitrile; 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile, E 2007, E-2007, E2007
• Empirische Formel (Hill-System): C₂₃H₁₅N₃O
• CAS-Nummer: 380917-97-5
• Molekulargewicht: 349.38
• MDL number: MFCD19443693
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• drug control: USDEA Schedule III
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

Perampanel is an orally active, noncompetitive AMPA receptor antagonist that inhibits 2 μM AMPA-, but not NMDA-, induced Ca2+ in cultured rat cortical neurones (IC50 = 93 nM) and display therapeutic efficacy in murine models of epilepsy in vivo (audiogenic, MES-induced, and PTZ-induced seizures in mice ED50 = 0.47, 1.6, and 0.94 mg/kg p.o., respectively) and a rat amygdala-kindling model (1-10 mg/kg p.o.).

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302,H413
• Sicherheitshinweise: P264 - P270 - P273 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 4
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable