SML4271

SN-011

≥98% (HPLC)

• Synonym(e): N-[3-[[(4-Fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl][1,1′-biphenyl]-4-carboxamide, SN-11, GUN35901
• Empirische Formel (Hill-System): C₂₅H₁₉FN₂O₄S
• CAS-Nummer: 2249435-90-1
• Molekulargewicht: 462.49
• MDL number: MFCD34469067
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

Potent, selective, and non-cytotoxic STING inhibitor that blocks STING signaling and inflammation in both in vitro and in vivo.



SN-011 is a potent, specific, and non-cytotoxic STING antagonist that binds to the STING cyclic dinucleotide (CDN)-binding domain with higher affinity than endogenous 2’3’-cGAMP. It locks the STING dimer in an open, inactive conformation and stalls STING-dependent signaling. SN-011 inhibits 2′3′-cGAMP-induced Ifnb expression (IC50 = 127.5, 107.1, and 502.8 nM in MEFs, mouse bone marrow-derived macrophages (BMDMs), and human foreskin fibroblasts (HFFs), respectively. It also suppresses the secretion of pro-inflammatory molecules in vitro mouse and human models, including HSV-1 infection and Trex1 deficiency in mice. SN-011 blocks the spontaneous activation of GOF STING mutants that cause STING-associated vasculopathy with onset in infancy (SAVI).

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H317
• Sicherheitshinweise: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable