1162002

Cytarabin

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): Cytosin β-D-Arabinofuranosid, (β-D-Arabinofuranosyl)-cytosin, Ara-C, Arabinocytidin, Arabinosylcytosin, Cytarabin, Cytosinarabinosid
• Empirische Formel (Hill-System): C₉H₁₃N₃O₅
• CAS-Nummer: 147-94-4
• Molekulargewicht: 243.22
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329749501
• MDL number: MFCD00066487
• Beilstein/REAXYS Number: 89175

Eigenschaften

• Produktname: Cytarabin, United States Pharmacopeia (USP) Reference Standard
• InChI: 1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
• SMILES string: NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
• InChI key: UHDGCWIWMRVCDJ-CCXZUQQUSA-N
• grade: pharmaceutical primary standard
• API family: cytarabine
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• Gene Information: human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558)

Beschreibung

Biochem/physiol Actions

Ara-C wird in DNA eingebaut und hemmt die DNA-Replikation durch Bildung von Spaltkomplexen mit Topoisomerase I, was zu einer Fragmentierung der DNA führt; die RNA-Synthese wird nicht gehemmt. Anti-Leukämiemittel.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Cytarabine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Cytarabine for Injection

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H317,H361fd
• pcodes: P202 - P261 - P272 - P280 - P302 + P352 - P308 + P313
• Hazard Classifications: Repr. 2 - Skin Sens. 1
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable