1162400

Dactinomycin

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): Actinomycin D, Actinomycin C₁, Actinomycin IV, Dactinomycin
• Empirische Formel (Hill-System): C₆₂H₈₆N₁₂O₁₆
• CAS-Nummer: 50-76-0
• Molekulargewicht: 1255.42
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329749507
• MDL number: MFCD00005033
• Beilstein/REAXYS Number: 605235

Eigenschaften

• grade: pharmaceutical primary standard
• agency: USP
• API family: dactinomycin
• manufacturer/tradename: USP
• color: red, powder
• mp: 251-253
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3OC4=C(C)C(=O)C(N)=C(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)C4=Nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]7CCCN7C1=O
• InChI: 1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
• InChI key: RJURFGZVJUQBHK-IIXSONLDSA-N

Beschreibung

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dactinomycin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Dactinomycin for Injection

Biochem/physiol Actions

Durch die Bildung eines stabilen Komplexes mit doppelsträngiger DNA hemmt Actinomycin D die Proliferation von Zellen, wodurch die DNA-primed RNA-Synthese gehemmt und einsträngige DNA-Brüche verursacht werden. Es ist nachweislich ein Inhibitor für den Minusstrangtransfer bei der reversen Transkriptase.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300,H350,H360FD
• pcodes: P201 - P202 - P264 - P270 - P280 - P301 + P310
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B - Repr. 1B
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable