1338007

Imipramin -hydrochlorid

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepin-5-propanamin -hydrochlorid, 5-[3-(Dimethylamino)-propyl]-10,11-dihydro-5H-dibenz[b,f]azepin -hydrochlorid
• Empirische Formel (Hill-System): C₁₉H₂₄N₂ · HCl
• CAS-Nummer: 113-52-0
• Molekulargewicht: 316.87
• NACRES: NA.24
• PubChem Substance ID: 329750156
• UNSPSC Code: 41116107
• MDL number: MFCD00012669

Eigenschaften

• grade: pharmaceutical primary standard
• agency: USP
• API family: imipramine
• manufacturer/tradename: USP
• application(s): pharmaceutical; pharmaceutical (small molecule)
• format: neat
• SMILES string: Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H
• InChI key: XZZXIYZZBJDEEP-UHFFFAOYSA-N
• Gene Information: human ... SLC6A2(6530), SLC6A4(6532)

Beschreibung

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Imipramine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Imipramine Hydrochloride Tablets
• Imipramine Hydrochloride Injection
• Desipramine Hydrochloride
• Clomipramine Hydrochloride
• Desipramine Hydrochloride Tablets
• Trimipramine Maleate

Biochem/physiol Actions

Tricyclisches Antidepressivum; hemmt die Serotonin- und Noradrenalin-Transporter mit K_is von 7.7 nM bzw. 67 nM. Hat wenig Einfluss auf Dopamin-Transporter (K_i = 25 μM).

Tricyclisches Antidepressivum; hemmt die Serotonin- und Noradrenalin-Transporter, hat wenig Einfluss auf Dopamin-Transporter.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral