1349706

Isoniazid

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): 4-Pyridincarbonsäurehydrazid, INH, Isonicotinsäurehydrazid
• Empirische Formel (Hill-System): C₆H₇N₃O
• CAS-Nummer: 54-85-3
• Molekulargewicht: 137.14
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750199
• MDL number: MFCD00006426
• Beilstein/REAXYS Number: 119374

Eigenschaften

• grade: pharmaceutical primary standard
• agency: USP
• API family: isoniazid
• manufacturer/tradename: USP
• mp: 171-173 °C (lit.)
• application(s): pharmaceutical; pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: NNC(=O)c1ccncc1
• InChI: 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
• InChI key: QRXWMOHMRWLFEY-UHFFFAOYSA-N

Beschreibung

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Isoniazid USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Isoniazid Tablets
• Isoniazid Injection
• Isoniazid Oral Solution
• Rifampin and Isoniazid Capsules
• Rifampin, Isoniazid, and Pyrazinamide Tablets
• Rifampin, Isoniazid, Pyrazinamide, and Ethambutol Hydrochloride Tablets

Biochem/physiol Actions

Antibiotikum für die Behandlung von Mycobacterium tuberculosis; inhibiert die Mycolsäure-Biosynthese. Wird von hepatischer N-Acetyltransferase (NAT) und Cytochrom P450 2E1 (CYP2E1) zu Hepatotoxinen metabolisert. Induziert selektiv die Expression von CYP2E1. Inhibiert Aktivitäten von CYP2C19 und CYP3A4 reversibel und inaktiviert CYP1A2, CYP2A6, CYP2C19 und CYP3A4 bei klinisch relevanten Konzentrationen.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302,H315
• Sicherheitshinweise: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Acute Tox. 4 Oral - Skin Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3