Inhibition of angiogenesis by antioxidant micelles.

Inhibition of angiogenesis by antioxidant micelles.

Advanced healthcare materials (2014-09-13)

Masaki Moriyama, Stéphanie Metzger, André J van der Vlies, Hiroshi Uyama, Martin Ehrbar, Urara Hasegawa

ZUSAMMENFASSUNG

Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken ex ovo chorioallantoic membrane assay. The results show that antioxidant micelles containing catechol moieties may be useful in anti-angiogenic therapy to treat various diseases such as cancer.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

34860

Sigma-Aldrich

Methanol, suitable for HPLC, ≥99.9%

D2650

Sigma-Aldrich

Dimethylsulfoxid, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

472301

Sigma-Aldrich

Dimethylsulfoxid, ACS reagent, ≥99.9%

T6508

Sigma-Aldrich

Trifluoressigsäure, ReagentPlus^®, 99%

179337

Sigma-Aldrich

Methanol, ACS reagent, ≥99.8%

258148

Sigma-Aldrich

Salzsäure, ACS reagent, 37%

D8418

Sigma-Aldrich

Dimethylsulfoxid, Molecular Biology

34869

Sigma-Aldrich

Dimethylsulfoxid, suitable for HPLC, ≥99.7%

302031

Sigma-Aldrich

Trifluoressigsäure, suitable for HPLC, ≥99.0%

34856

Sigma-Aldrich

Dichlormethan, suitable for HPLC, ≥99.8%, contains amylene as stabilizer

319902

Sigma-Aldrich

Ethylacetat, ACS reagent, ≥99.5%

319937

Sigma-Aldrich

N,N-Dimethylformamid, ACS reagent, ≥99.8%

D2438

Sigma-Aldrich

Dimethylsulfoxid, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

270547

Sigma-Aldrich

N,N-Dimethylformamid, suitable for HPLC, ≥99.9%

34858

Sigma-Aldrich

Ethylacetat, suitable for HPLC, ≥99.7%

673811

Sigma-Aldrich

Diethylether, anhydrous, ACS reagent, ≥99.0%, contains BHT as inhibitor

D65100

Sigma-Aldrich

Dichlormethan, contains 40-150 ppm amylene as stabilizer, ACS reagent, ≥99.5%

216763

Sigma-Aldrich

Wasserstoffperoxid -Lösung, contains inhibitor, 30 wt. % in H₂O, ACS reagent

239313

Sigma-Aldrich

Natriumsulfat, ACS reagent, ≥99.0%, anhydrous, granular

D5879

Sigma-Aldrich

Dimethylsulfoxid, ReagentPlus^®, ≥99.5%

650463

Sigma-Aldrich

Dichlormethan, HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%, contains 50-150 ppm amylene as stabilizer

238597

Sigma-Aldrich

Natriumsulfat, ACS reagent, ≥99.0%, anhydrous, powder

443778

Sigma-Aldrich

1-Methyl-2-pyrrolidon, ACS reagent, ≥99.0%

227056

Sigma-Aldrich

N,N-Dimethylformamid, anhydrous, 99.8%

276855

Sigma-Aldrich

Dimethylsulfoxid, anhydrous, ≥99.9%

H1009

Sigma-Aldrich

Wasserstoffperoxid -Lösung, 30 % (w/w) in H₂O, contains stabilizer

646377

Sigma-Aldrich

Methanol, HPLC Plus, ≥99.9%

320331

Sigma-Aldrich

Salzsäure, ACS reagent, 37%

650528

Sigma-Aldrich

Ethylacetat, HPLC Plus, for HPLC, GC, and residue analysis, 99.9%

309966

Sigma-Aldrich

Diethylether, suitable for HPLC, ≥99.9%, inhibitor-free