A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis.

A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis.

Cell (2017-10-21)

Roopa Hebbandi Nanjundappa, Francesca Ronchi, Jinguo Wang, Xavier Clemente-Casares, Jun Yamanouchi, Channakeshava Sokke Umeshappa, Yang Yang, Jesús Blanco, Helena Bassolas-Molina, Azucena Salas, Hamza Khan, Robyn M Slattery, Madeleine Wyss, Catherine Mooser, Andrew J Macpherson, Laura K Sycuro, Pau Serra, Derek M McKay, Kathy D McCoy, Pere Santamaria

PMID29053971

ZUSAMMENFASSUNG

The gut microbiota contributes to the development of normal immunity but, when dysregulated, can promote autoimmunity through various non-antigen-specific effects on pathogenic and regulatory lymphocytes. Here, we show that an integrase expressed by several species of the gut microbial genus Bacteroides encodes a low-avidity mimotope of the pancreatic β cell autoantigen islet-specific glucose-6-phosphatase-catalytic-subunit-related protein (IGRP

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

10771

Sigma-Aldrich

Histopaque^®-1077, sterile-filtered, density: 1.077

H4522

Sigma-Aldrich

Humanserum, from human male AB plasma, USA origin, sterile-filtered

L4391

Sigma-Aldrich