• Início
  • Resultados da busca
  • Synthetic ion transporters: pore formation in bilayers via coupled activity of non-spanning cobalt-cage amphiphiles.

Synthetic ion transporters: pore formation in bilayers via coupled activity of non-spanning cobalt-cage amphiphiles.

Biochimica et biophysica acta (2014-02-11)
Lorale J Lalgee, Lebert Grierson, Richard A Fairman, Gina E Jaggernauth, Albert Schulte, Roland Benz, Mathias Winterhalter
RESUMO

Three amphiphilic cobalt-cage congeners bearing a diaza-crown bridge and varying alkyl chains (1:2:3; n = 12, 16, 18) have been assessed for their ion transport across planar lipid bilayer membranes. In symmetrical electrolyte solutions, a range of ion transport activity is provoked: 1 disrupts painted (fluid) bilayers in a detergent-like mode of action; 2 forms conducting "pores" in folded (rigid) membranes with long open lifetimes (>2 min) while 3 requires the larger auxiliary solvent volume and lower lateral stress of painted membranes to effect ion transport via long-lived pores. Hill analysis of the conductance variation with monomer concentration yields coefficients (2:3; n = 2.3, 1.9) in support of dimeric (n = 2) membrane-active structures, for which the derived "pore" radii are correlated with charge-density of the transported cations and their affinity for the crown moiety. A toroidal-pore model is invoked to account for the flux of guest ions through planar bilayer membranes without a fast-diffusing intermediary or direct membrane-spanning structure.

MATERIAIS
Número do produto
Marca
Descrição do produto

Sigma-Aldrich
Cobalt, powder, 2 μm particle size, 99.8% trace metals basis
Sigma-Aldrich
Cobalt, powder, <150 μm, ≥99.9% trace metals basis
Sigma-Aldrich
Cobalt, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%
Sigma-Aldrich
Cobalt, granular, 99.99% trace metals basis
Sigma-Aldrich
Cobalt, foil, thickness 0.1 mm, 99.95% trace metals basis
Sigma-Aldrich
Cobalt, pieces, 99.5% trace metals basis
Sigma-Aldrich
Cobalt, foil, thickness 1.0 mm, 99.95% trace metals basis
Sigma-Aldrich
Cobalt, rod, diam. 5.0 mm, 99.95% trace metals basis
Cobalt, foil, 25mm disks, thickness 0.05mm, annealed, 99.9%
Cobalt, foil, 25mm disks, thickness 0.05mm, as rolled, 99.9%
Cobalt, foil, 25mm disks, thickness 0.125mm, annealed, 99.9%
Cobalt, foil, 25mm disks, thickness 0.25mm, as rolled, 99.9%
Cobalt, foil, 25mm disks, thickness 0.25mm, as rolled, 99.99+%
Cobalt, foil, 4mm disks, thickness 0.003mm, 99.9%
Cobalt, foil, 4mm disks, thickness 0.004mm, 99.9%
Cobalt, foil, 4mm disks, thickness 0.005mm, 99.9%
Cobalt, foil, 4mm disks, thickness 0.006mm, 99.9%
Cobalt, foil, 4mm disks, thickness 0.007mm, 99.9%
Cobalt, foil, 4mm disks, thickness 0.008mm, 99.9%
Cobalt, foil, 4mm disks, thickness 0.009mm, 99.9%
Cobalt, foil, 4mm disks, thickness 0.0125mm, 99.9%
Cobalt, foil, 4mm disks, thickness 0.015mm, 99.9%
Cobalt, foil, 4mm disks, thickness 0.01mm, 99.9%
Cobalt, foil, 4mm disks, thickness 0.025mm, 99.9%
Cobalt, foil, 4mm disks, thickness 0.02mm, 99.9%
Cobalt, foil, 4mm disks, thickness 0.05mm, annealed, 99.9%
Cobalt, foil, 4mm disks, thickness 0.05mm, as rolled, 99.9%
Cobalt, foil, 4mm disks, thickness 0.05mm, as rolled, 99.99+%
Cobalt, foil, 4mm disks, thickness 0.125mm, annealed, 99.9%
Cobalt, foil, 4mm disks, thickness 0.125mm, as rolled, 99.99+%

Redes sociais

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

Pesquisa. Desenvolvimento. Produção.

Somos um fornecedor global líder para o setor de ciências biológicas, com soluções e serviços para pesquisa, desenvolvimento e produção de biotecnologia, além de produção e desenvolvimento de terapias farmacológicas com medicamentos.

© 2021 Merck KGaA, Darmstadt, Alemanha e/ou suas filiais. Todos os direitos reservados.

A reprodução não autorizada de quaisquer materiais deste site é estritamente proibida.