SMC1A
structural maintenance of chromosomes 1A
Synonyme:
CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Spezies:
Human SMC1A (8243), Mouse Smc1a (24061), Rat Smc1a (63996), Zebrafish smc1a (559665), sheep SMC1A (101120550), dog SMC1A (480928), domestic cat SMC1A (101090170), naked mole-rat Smc1a (101713253), cow SMC1A (282370), chicken SMC1A (395187)
UniProtKB-ID:
Gen-ID:
- Human(8243) Summary: Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq, Jul 2008]
- Mouse(24061) structural maintenance of chromosomes 1A
- Rat(63996) structural maintenance of chromosomes 1A
- Zebrafish(559665) structural maintenance of chromosomes 1A
- sheep(101120550) structural maintenance of chromosomes 1A
- dog(480928) structural maintenance of chromosomes 1A
- domestic cat(101090170) structural maintenance of chromosomes 1A
- naked mole-rat(101713253) structural maintenance of chromosomes 1A
- cow(282370) structural maintenance of chromosomes 1A
- chicken(395187) structural maintenance of chromosomes 1A
- domestic guinea pig(100723138) structural maintenance of chromosomes 1A
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Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-p-SMC1A (Ser966) Antibody, clone 1B11 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Speziesreaktivität
human
Anwendung
immunocytochemistry
inhibition assay
western blot
inhibition assay
western blot
Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5 Alexa Fluor™ 488, clone 5D11G5, from mouse, ALEXA FLUOR™ 488,
Speziesreaktivität
xenopus, bovine, human
Anwendung
flow cytometry
western blot
western blot
Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5, clone 5D11G5, Upstate®, from mouse,
Speziesreaktivität
human, mouse
Anwendung
western blot
Anti-SMC1 antibody produced in rabbit, ,
Speziesreaktivität
human, mouse, rat
Anwendung
immunohistochemistry
western blot
western blot
Anti-Phospho-SMC1A-S957 antibody produced in rabbit, ,
Speziesreaktivität
human, mouse, rat
Anwendung
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot