14-680

HIPK3 Protein, active, 10 µg

• UNSPSC-Code: 12352202
• eCl@ss: 32160405

Eigenschaften

• Rekombinant: expressed in baculovirus infected Sf21 cells
• Qualitätsniveau: 100
• Beschreibung: protein target HIPK3
• Aufgereinigt durch: (Ni²⁺/NTA-agarose)
• Methode(n): activity assay: suitable
• UniProt-Hinterlegungsnummer: Q9H422
• Angaben zum Gen: human ... HIPK3(10114)

Beschreibung

Allgemeine Beschreibung

49.7kDa

FUNCTION: SwissProt: Q9H422 # Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.
SIZE: 1215 amino acids; 133743 Da
SUBUNIT: Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.
PTM: Autophosphorylated, but autophosphorylation is not required for catalytic activity (By similarity). & May be sumoylated (By similarity).
SIMILARITY: SwissProt: Q9H422 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. & Contains 1 protein kinase domain.

Angaben zur Herstellung

Stable 6 months at -70°C from date of shipment

Hinweis zur Analyse

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

routinely evaluated by phosphorylation of MBP (Catalog # 13-104)

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H317
• P-Sätze: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Gefahreneinstufungen: Skin Sens. 1
• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable