SML3288

WX8

≥98% (HPLC)

• Synonym(e): 1H-Indole-3-carbaldehyde [4-anilino-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone, 1H-Indole-3-carboxaldehyde, [4-(4-morpholinyl)-6-(phenylamino)-1,3,5-triazin-2-yl]hydrazone, Ro 91-4714, Ro-91-4714
• Empirische Formel (Hill-System): C₂₂H₂₂N₈O
• CAS-Nummer: 232935-92-1
• Molekulargewicht: 414.46
• UNSPSC Code: 12352200
• NACRES: NA.77

Eigenschaften

• Produktname: WX8, ≥98% (HPLC)
• InChI key: NJIKLALXAPYTCW-BUVRLJJBSA-N
• SMILES string: C1(NC2=CC=CC=C2)=NC(N/N=C/C3=CNC4=C3C=CC=C4)=NC(N5CCOCC5)=N1
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• Quality Level: 100

Beschreibung

Biochem/physiol Actions

Selective phosphoinositide kinase PIKfyve inhibitor with higher antiproliferation potency in A375 cultures than YM201636, chloroquine or hydroxychloroquine.

WX8 (Ro 91-4714) is a selective phosphoinositide kinase PIKfyve inhibitor that disrupts lysosome fission via tubulation, lysosomal trafficking, and heterotypic lysosomes-autophagosomes fusion (0.1-1 µM; U2OS), but not homotypic lysosome fusion. WX8 exhibits cancer-selective antiproliferation activity (IC50 = 48 nM/A375, 200 nM/U2OS; IC50 >10 µM/non-cancer 293T & HFF) with a higher potency than the PIKfyve inhibitor YM201636, or the lysosomal inhibitors chloroquine & hydroxychloroquine (A375 IC50 = 119 nM, 1.7 µM, 1.9 µM, repectively).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable