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Synthesis of [2H7]indatraline.

Synthesis of [2H7]indatraline.

Journal of labelled compounds & radiopharmaceuticals (2014-11-11)

L Allmendinger, K T Wanner

ZUSAMMENFASSUNG

Deuterium-labelled indatraline was synthesized in high efficiency employing a Friedel-Crafts alkylation of [(2)H6]benzene with (E)-3-(3,4-dichlorophenyl)acrylic acid as a key step. The desired labelling of the final compound was ascertained in two ways, by incorporation of [(2)H6]benzene in the target molecule and additionally by deuterium transfer to the non-deuterated aryl moiety of the Friedel-Crafts alkylation product from [(2)H6]benzene, the latter thus serving as reagent and solvent.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

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N,N-Dimethylformamid, ACS reagent, ≥99.8%

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N,N-Dimethylformamid, suitable for HPLC, ≥99.9%

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Benzol, suitable for HPLC, ≥99.9%

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Benzol, ACS reagent, ≥99.0%

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Aluminiumchlorid, ReagentPlus^®, 99%

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Benzol, analytical standard

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Aluminiumchlorid, reagent grade, 98%

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N,N-Dimethylformamid, ReagentPlus^®, ≥99%

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N,N-Dimethylformamid, Molecular Biology, ≥99%

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Benzol, anhydrous, 99.8%

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Methansulfonylchlorid, ≥99.7%

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Methylamin -Lösung, 33 wt. % in absolute ethanol ((denatured with 1% toluene))

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Thionylchlorid, ReagentPlus^®, ≥99%

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Methylamin -Lösung, 40 wt. % in H₂O

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Methylamin -Lösung, 2.0 M in THF

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Aluminiumchlorid, anhydrous, powder, 99.999% trace metals basis

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