SML1410

A-366

≥98% (HPLC)

• Synonyme(s) : 5′-Methoxy-6′-[3-(1-pyrrolidinyl)propoxy]-spiro[cyclobutane-1,3′-[3H]indol]-2′-amine
• Formule empirique (notation de Hill) : C₁₉H₂₇N₃O₂
• Numéro CAS: 1527503-11-2
• Poids moléculaire : 329.44
• NACRES: NA.77
• PubChem Substance ID: 329825857
• UNSPSC Code: 12352202
• MDL number: MFCD28133403

Propriétés

• Nom du produit: A-366, ≥98% (HPLC)
• InChI key: BKCDJTRMYWSXMC-UHFFFAOYSA-N
• SMILES string: NC1=NC2=CC(OCCCN3CCCC3)=C(OC)C=C2C14CCC4
• InChI: 1S/C19H27N3O2/c1-23-16-12-14-15(21-18(20)19(14)6-4-7-19)13-17(16)24-11-5-10-22-8-2-3-9-22/h12-13H,2-11H2,1H3,(H2,20,21)
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• Quality Level: 100

Description

Biochem/physiol Actions

A-366 is an SGC chemical probe for G9a/GLP, developed in collaboration with Abbvie. A-366 is a potent, selective inhibitor of the histone methyltransferase G9a. The IC₅₀ values for G9a inhbition in enzymatic and cell based assays are 3.3 and approximately 3 μM, respectively. A-366 has little or no detectable activity against a panel of 21 other methyltransferases. For full characterization details, please visit the A-366 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

A-366 is potent, selective inhibitor of the histone methyltransferase G9a.

Features and Benefits

A-366 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

A-366 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the A-366 probe summary on the Chemical Probes Portal website.

Informations sur la sécurité

• pictograms: GHS09
• signalword: Warning
• hcodes: H400
• pcodes: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable