05-588

Anti-HET/SAF-B Antibody, clone 6F7

Name: Anti-HET/SAF-B Antibody, clone 6F7
Brand: MM
Price: 355 CHF

clone 6F7, Upstate^®, from mouse

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200 μG

CHF 355.00

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Informazioni su questo articolo

Codice UNSPSC:

12352203

eCl@ss:

32160702

NACRES:

NA.41

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Origine biologica

mouse

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

6F7, monoclonal

Reattività contro le specie

human

Produttore/marchio commerciale

Upstate^®

tecniche

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG

N° accesso NCBI

NM_002555

N° accesso UniProt

Q15424

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... SAFB(6294)

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Questo articolo	05-486	MABC1176	MABS1990M
Sigma-Aldrich 05-588 Anti-HET/SAF-B Antibody, clone 6F7	Sigma-Aldrich 05-486 Anti-FADD Antibody, clone 1F7	Sigma-Aldrich MABC1176 Anti-Bax Antibody, clone 6A7	Sigma-Aldrich MABS1990M Anti-RhoB Antibody, clone 7F7
clone 6F7, monoclonal	clone 1F7, monoclonal	clone monoclonal	clone 7F7, monoclonal
species reactivity human	species reactivity mouse, human	species reactivity human	species reactivity rat, mouse, hamster, porcine, human, chicken, monkey, rabbit
biological source mouse	biological source mouse	biological source mouse	biological source mouse
antibody form purified immunoglobulin	antibody form purified antibody	antibody form purified antibody	antibody form purified immunoglobulin
UniProt accession no. Q15424	UniProt accession no. Q13158	UniProt accession no. Q07812	UniProt accession no. P62745
Gene Information human ... SAFB(6294)	Gene Information human ... FADD(8772) mouse ... Fadd(14082)	Gene Information human ... BAX(581)	Gene Information human ... RHOB(388)

Descrizione generale

130kDa

Immunogeno

Peptide corresponding to residues 345-357 of human HET/SAF-B

Applicazioni

Anti-HET/SAF-B Antibody, clone 6F7 is a high quality Mouse Monoclonal Antibody for the detection of HET/SAF-B & has been validated in IP, WB, ICC & IHC.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

Azioni biochim/fisiol

HET/SAF-B

Stato fisico

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%

Format: Purified

Protein G Chromatography

Nota sulla preparazione

2 years at -20°C

Risultati analitici

routinely evaluated by immunoblot on whole cell extracts or RIPA lysates from MCF-7 cells

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Certificati d'analisi (COA)

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Tamoxifen-bound estrogen receptor (ER) strongly interacts with the nuclear matrix protein HET/SAF-B, a novel inhibitor of ER-mediated transactivation.

S Oesterreich et al.

Molecular endocrinology (Baltimore, Md.), 14(3), 369-381 (2000-03-09)

The estrogen receptor (ER) is a ligand-dependent transcription factor that acts in a cell- and promoter-specific manner. Evidence suggests that the activity of the ER can be regulated by a number of other stimuli (e.g. growth factors) and that the

iCLIP identifies novel roles for SAFB1 in regulating RNA processing and neuronal function.

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SAFB1 is a RNA binding protein implicated in the regulation of multiple cellular processes such as the regulation of transcription, stress response, DNA repair and RNA processing. To gain further insight into SAFB1 function we used iCLIP and mapped its

Eight-plex iTRAQ labeling and quantitative proteomic analysis for human bladder cancer.

Qimin Zhang et al.

American journal of cancer research, 7(4), 935-945 (2017-05-05)

Bladder cancer is one of the most prevalent cancers worldwide, and increasing research has focused on new technologies for early detection of bladder cancer. For example, proteomic techniques for biomarker discovery have been implemented for the detection and analysis of

B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress.

E Werwein et al.

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B-Myb is a highly conserved member of the Myb transcription factor family that has essential roles in cell-cycle progression. Recent work has suggested that B-Myb is also involved in the cellular DNA-damage response. Here, we have investigated the fate of

SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor.

Steven M Townson et al.

The Journal of biological chemistry, 278(22), 20059-20068 (2003-03-28)

We have characterized previously the nuclear matrix protein/scaffold attachment factor (SAFB) as an estrogen receptor corepressor and as a potential tumor suppressor gene in breast cancer. A search of the human genome for other potential SAFB family members revealed that

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