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Merck

AB2202

Anti-PER2 Antibody

serum, Chemicon®

Sinonimo/i:

Anti-FASPS, Anti-FASPS1

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Informazioni su questo articolo

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Documenti fondamentali

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Origine biologica

rabbit

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

serum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Reattività contro le specie

mouse, rat

Produttore/marchio commerciale

Chemicon®

tecniche

western blot: suitable

N° accesso NCBI

NP_035196

N° accesso UniProt

O54943

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

mouse ... Per2(18627)

Categorie correlate

Descrizione generale

Approx. 136 kDa Band may be observed at a much higher 200 kDa by the liver product depending on level of phophorylation and gel system used.
PER2 is a component of the circadian clock mechanism which is essential for generating circadian rhythms. It is a negative element in the circadian transcriptional loop by Influencing clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. PER2 negatively regulates CLOCK NPAS2-BMAL1 BMAL2-induced transactivation. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.

Immunogeno

Synthetic peptide.

Applicazioni

Anti-PER2 Antibody detects level of PER2 & has been published & validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Circadian Rhythm & Sleep
Western Blot Analysis:
C2C12 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-PER2 (1:500 dilution of this lot). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.

Azioni biochim/fisiol

Cat. # AB2202 will recognize the N-terminus of PER2.
Reactivity with other species has not been determined.

Stato fisico

Serum with 0.05% NaN3

Nota sulla preparazione

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

Risultati analitici

Control
C2C12 tissue lysate.
Routinely evaluated by western blot on C2C12 lysate.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Peiyuan Qiu et al.
National science review, 6(1), 87-100 (2019-01-01)
Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey
Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body.
Evans, JA; Suen, TC; Callif, BL; Mitchell, AS; Castanon-Cervantes, O; Baker, KM; Kloehn et al.
BMC Biology null
Tomoko Yoshikawa et al.
eNeuro, 8(5) (2021-08-14)
Biological neural networks operate at several levels of granularity, from the individual neuron to local neural circuits to networks of thousands of cells. The daily oscillation of the brain's master clock in the suprachiasmatic nucleus (SCN) rests on a yet
Youli Yao et al.
Frontiers in physiology, 11, 294-294 (2020-05-12)
Alzheimer's disease (AD) patients often exhibit perturbed circadian rhythm with fragmented sleep before disease onset. This study was designed to evaluate the effect of a 40-Hz light flicker on circadian rhythm in an AD mouse model (APP/PS1). Locomotor rhythms recordings
Jennifer Gile et al.
Current pharmaceutical design, 26(34), 4330-4337 (2020-04-16)
We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction. Based on previous studies showing a critical role for the adenosine A2B receptor (ADORA2B) in PER2 regulation, we hypothesized that hippocampal ADORA2B
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