PHR1237

Colecalciferolo

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinonimo/i: (+)-Vitamina D₃, 7-deidrocolesterolo attivato, Calciol
• Formula empirica (notazione di Hill): C₂₇H₄₄O
• Numero CAS: 67-97-0
• Peso molecolare: 384.64
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329823242
• EC Number: 200-673-2
• Beilstein/REAXYS Number: 2339331
• MDL number: MFCD00078131

Proprietà

• Quality Segment: 300
• grade: certified reference material, pharmaceutical secondary standard
• agency: USP 1131009, traceable to Ph. Eur. C2100000
• API family: cholecalciferol
• form: solid
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• mp: 83-86 °C (lit.)
• application(s): cosmetics; food and beverages; pharmaceutical
• format: neat
• storage temp.: -10 to -25°C
• SMILES string: CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
• InChI: 1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
• InChI key: QYSXJUFSXHHAJI-YRZJJWOYSA-N
• Gene Information: human ... VDR(7421)

Descrizione

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cholecalciferol (vitamin D3) is a fat-soluble vitamin that manifests skeletal and extra-skeletal effects. The skeletal effects augment the bone health whereas the extra-skeletal effects concern the immune system, the cognition, the cardiovascular system, etc.

Application

Cholecalciferol (Vitamin D3) may be used as a pharmaceutical reference standard for the determination of the analyte in food, feeds, serum samples and pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

La vitamina D agisce attraverso un recettore che modula la proliferazione e la differenziazione delle cellule sia normali, sia tumorali.

La vitamina D agisce attraverso un recettore che è un membro della superfamiglia dei fattori di trascrizione ligando-dipendenti. Modula la proliferazione e la differenziazione sia delle cellule normali che tumorali. Ha effetti antiproliferativi e antimetastatici sulle cellule del cancro della mammella, del colon e della prostata. I recettori della vitamina D attivati nell'intestino e nelle ossa sono responsabili della regolazione dell'assorbimento e dell'omeostasi del calcio.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC0270 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Parola di avvertenza: Danger
• Codici di pericolo: H300 + H310 + H330,H372
• Avvertenze di sicurezza: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral
• Classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Che succede?: WGK 2
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable