We have not tested the cell membrane permeability of Product 90790, L-α-Hydroxyglutaric acid disodium salt. A helpful reference discussing the use of L-α-Hydroxyglutaric acid disodium salt to treat zebrafish is listed below.Parng, C. et al., Neurotoxicology and Teratology, 28, 509-516 , (2006).
90790
L-α-Hydroxyglutaric acid disodium salt
≥98.0% (GC)
Sinonimo/i:
(S)-2-Hydroxypentanedioic acid disodium salt, Disodium (S)-2-hydroxyglutarate
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10 MG
CHF 74.50
50 MG
CHF 299.00
Informazioni su questo articolo
Formula condensata:
C5H6O5Na2
Numero CAS:
Peso molecolare:
192.08
Beilstein:
5318042
Numero MDL:
Codice UNSPSC:
12352106
ID PubChem:
NACRES:
NA.32
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Permettici di aiutartiLivello qualitativo
Saggio
≥98.0% (GC)
Stato
powder or crystals
Attività ottica
[α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH
Impurezze
≤6.0% water
Malattie correlate
cancer
Temperatura di conservazione
2-8°C
Stringa SMILE
[O-]C(CC[C@@H](C([O-])=O)O)=O.[Na+].[Na+]
InChI
1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1
DZHFTEDSQFPDPP-QTNFYWBSSA-L
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Questo articolo | H8378 | 94577 | 16859 |
|---|---|---|---|
| assay ≥98.0% (GC) | assay ≥95% (GC) | assay ≥95.0% (GC) | assay ≥98.0% (GC) |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| form powder or crystals | form powder | form powder or crystals | form powder or crystals |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| optical activity [α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH | optical activity - | optical activity - | optical activity [α]/D 8.5±1.5°, c = 1 in NaOH |
| impurities ≤6.0% water | impurities - | impurities ≤6.0% water | impurities ≤6.0% water |
Descrizione generale
Applicazioni
L-α-Hydroxyglutaric acid disodium salt is suitable for use in collection buffer for increased recovery of hypoxia-inducible factor-1 α (HIF-1α), a marker of hypoxia in human tumors.[4] It is also suitable for the radiolabeled 5mC-5hmC conversion assay to study the effect of 2-HG on the TET family of methyl hydroxylases.[5]
Azioni biochim/fisiol
L-alpha-Hydroxyglutaric acid accumulates as a result of a rare defect in L-2-HG dehydogenase, leading to the metabolic disorder L-2-hydroxyglutaric aciduria (L-2HGA). L-2HGA is associated with neuronal defects, leukodystrophy and linked to an increased risk of brain tumors.
Confezionamento
Bottomless glass bottle. Contents are inside inserted fused cone.
used together
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Hugh Colvin et al.
Scientific reports, 6, 36289-36289 (2016-11-09)
Deranged metabolism is a hallmark of cancer, playing a significant role in driving the disease process. One such example is the induction of carcinogenesis by the oncometabolite D-2 hydroxyglutarate (D-2HG), which is produced by the mutated enzyme isocitrate dehydrogenase (IDH)
Rapid separation of some common intermediates of microbial metabolism by thin-layer chromatography.
A S Bleiweis et al.
Analytical biochemistry, 20(2), 335-338 (1967-08-01)
A S Bleiweis et al.
Journal of bacteriology, 94(5), 1560-1564 (1967-11-01)
Aspergillus glaucus, cultured on sodium propionate-mineral salts medium, incorporates (14)C-glyoxylate into labeled alpha-hydroxyglutaric acid within 30 sec. Mycelial extracts retain this biosynthetic capacity, which is destroyed by heating. Propionyl-2-(14)C-coenzyme A also in incorporated into labeled alpha-hydroxyglutaric acid by these mycelial
The production of alpha-hydroxyglutaric acid from glutamic acid by cell-free preparations of Peptococcus aerogenes.
W M Johnson et al.
Canadian journal of biochemistry, 47(12), 1103-1107 (1969-12-01)
Xudong Fu et al.
Cell metabolism, 22(3), 508-515 (2015-07-21)
We discovered recently that the central metabolite α-ketoglutarate (α-KG) extends the lifespan of C. elegans through inhibition of ATP synthase and TOR signaling. Here we find, unexpectedly, that (R)-2-hydroxyglutarate ((R)-2HG), an oncometabolite that interferes with various α-KG-mediated processes, similarly extends
Protocolli
We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.
Chromatograms
application for HPLC
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Is Product 90790, L-α-Hydroxyglutaric acid disodium salt cell membrane permeable?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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