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D7693
Dynasore
≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor
Sinonimo/i:
3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide
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Cambia visualizzazione
| Voi/SKU | Disponibilità | Prezzo |
|---|---|---|
5 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 184.00 |
25 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 728.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C18H14N2O4 · xH2O
Numero CAS:
Peso molecolare:
322.31 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
powder
Storage condition:
protect from light
Servizio Tecnico
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Permettici di aiutartiNome del prodotto
Dynasore,
form
powder
Quality Segment
storage condition
protect from light
color
off-white
solubility
DMSO: ≥10 mg/mL, H2O: insoluble
storage temp.
−20°C
SMILES string
O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
InChI
1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
InChI key
FKWZHQSDBMSHTN-ZIOFAICLSA-N
General description
Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.
Application
Dynasore hydrate has been used:
- for priming fetal mesenchymal stem/stromal cells (fMSC)
- in confocal microscopy
- in wound healing/scratch and tube-formation assay
- to analyse its effects on Coxsackievirus A9 (CAV9) infection
- to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
- in live imaging of cells
Biochem/physiol Actions
Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Questo articolo | |||
|---|---|---|---|
| description - | description ≥98% (HPLC) | description The Dynamin Inhibitor IV, Hydroxy-Dynasore controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Cell Signaling applications. | description The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications. |
| form powder | form powder | form solid | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition protect from light | storage condition protect from light | storage condition OK to freeze, protect from light | storage condition OK to freeze, protect from light |
| solubility DMSO: ≥10 mg/mL, H2O: insoluble | solubility DMSO: >10 mg/mL | solubility DMSO: 100 mg/mL | solubility DMSO: 16 mg/mL |
| color off-white | color faintly yellow to dark yellow | color yellow | color pale yellow |
Parola di avvertenza
Warning
Codici di pericolo
Avvertenze di sicurezza
Hazard Classifications
Aquatic Acute 1
Classe di stoccaggio
11 - Combustible Solids
Che succede?
WGK 3
Punto di infiammabilità (°F)
Not applicable
Punto di infiammabilità (°C)
Not applicable
DPI (dispositivi di protezione individuale)
Eyeshields, Gloves
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What is the Department of Transportation shipping information for this product?
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Helpful?
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How can I store a solution of Product D7693, Dynasore hydrate?
1 answer-
We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
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What can I use to make a solution of Product D7693, Dynasore hydrate?
1 answer-
As listed on the product page on the website, Dynasore is soluble in DMSO at 10 mg/mL. It is also soluble in ethanol at 1 mg/mL.
Helpful?
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What concentration of Product D7693, Dynasore hydrate, should I use in my experiment?
1 answer-
The following reference uses Dynasore at 80 μM: Massol, R.H., et al., A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc. Nat. Acad. Sci., USA, 103, 10265-10270 (2006).
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