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D7693

Dynasore

≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor

Sinonimo/i:

3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide

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Cambia visualizzazione
Voi/SKUDisponibilitàPrezzo
5 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 184.00
25 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 728.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C18H14N2O4 · xH2O
Numero CAS:
1202867-00-2
Peso molecolare:
322.31 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329798784
NACRES:
NA.77
MDL number:
MFCD11045288
Form:
powder
Storage condition:
protect from light

CHF 184.00

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Nome del prodotto

Dynasore,

form

powder

Quality Segment

storage condition

protect from light

color

off-white

solubility

DMSO: ≥10 mg/mL, H2O: insoluble

storage temp.

−20°C

SMILES string

O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O

InChI

1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;

InChI key

FKWZHQSDBMSHTN-ZIOFAICLSA-N

General description

Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization. Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.

Application

Dynasore hydrate has been used:
  • for priming fetal mesenchymal stem/stromal cells (fMSC)
  • in confocal microscopy
  • in wound healing/scratch and tube-formation assay
  • to analyse its effects on Coxsackievirus A9 (CAV9) infection
  • to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis
  • in live imaging of cells

Biochem/physiol Actions

Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pittogrammi

Environment
GHS09

Parola di avvertenza

Warning

Codici di pericolo

H400

Avvertenze di sicurezza

P273

Hazard Classifications

Aquatic Acute 1

Classe di stoccaggio

11 - Combustible Solids

WGK

WGK 3

Punto di infiammabilità (°F)

Not applicable

Punto di infiammabilità (°C)

Not applicable

DPI (dispositivi di protezione individuale)

Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number

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Questions

1–4 of 4 Questions  

  1. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  2. How can I store a solution of Product D7693, Dynasore hydrate?

    1 answer

    1. We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use.  We recommend storing at -20°C in single use aliquots.

      Helpful?

  3. What concentration of Product D7693, Dynasore hydrate, should I use in my experiment?

    1 answer

    1. The following reference uses Dynasore at 80 μM:  Massol, R.H., et al., A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating.  Proc. Nat. Acad. Sci., USA, 103, 10265-10270 (2006).

      Helpful?

  4. What can I use to make a solution of Product D7693, Dynasore hydrate?

    1 answer

    1. As listed on the product page on the website, Dynasore is soluble in DMSO at 10 mg/mL.  It is also soluble in ethanol at 1 mg/mL.

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