In situ nanofabrication of hybrid PEG-dendritic-inorganic nanoparticles and preliminary evaluation of their biocompatibility.

In situ nanofabrication of hybrid PEG-dendritic-inorganic nanoparticles and preliminary evaluation of their biocompatibility.

Nanoscale (2014-12-23)

Ana Sousa-Herves, Christian Sánchez Espinel, Amir Fahmi, África González-Fernández, Eduardo Fernandez-Megia

ABSTRACT

An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal molar ratio. The biocompatibility of the generated nanoparticles analysed in terms of their aggregation in physiological media, cytotoxicity and uptake by macrophages relates to the PEG density of the surface of the hybrids.

MATERIALI

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Marchio

Descrizione del prodotto

S6014

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Bicarbonato di sodio, ACS reagent, ≥99.7%

221864

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Bromuro di potassio, ≥99% trace metals basis

S5761

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Bicarbonato di sodio, powder, BioReagent, Molecular Biology, suitable for cell culture, suitable for insect cell culture

360538

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tert-Butanol, ACS reagent, ≥99.0%

S8875

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Bicarbonato di sodio, ReagentPlus^®, ≥99.5%, powder

243418

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Bromuro di potassio, ACS reagent, ≥99.0%

A7631

Sigma-Aldrich

(+)- L-ascorbato di sodio, crystalline, ≥98%

308250

Sigma-Aldrich

tert-Butanol, suitable for HPLC, ≥99.5%

792519

Sigma-Aldrich

Bicarbonato di sodio, anhydrous, free-flowing, Redi-Dri^™, ACS reagent, ≥99.7%

13433

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Bicarbonato di sodio, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E500, 99.0-100.5%, powder

11140

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(+)- L-ascorbato di sodio, BioXtra, ≥99.0% (NT)

24127

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tert-Butanol, ≥99% (GC)

A4034

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(+)- L-ascorbato di sodio, powder, BioReagent, suitable for cell culture

19460

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tert-Butanol, puriss. p.a., ACS reagent, ≥99.7% (GC)

471712

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tert-Butanol, anhydrous, ≥99.5%

746444

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Bromuro di potassio, anhydrous, free-flowing, Redi-Dri^™, ACS reagent, ≥99%

P16621

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Acido fenilacetico, 99%

S6297

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Bicarbonato di sodio, BioXtra, 99.5-100.5%

1613655

USP

Bicarbonato di sodio, United States Pharmacopeia (USP) Reference Standard

P9881

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Bromuro di potassio, ReagentPlus^®, ≥99.0%

232211

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4-Pentynoic acid, 95%

60089

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Bromuro di potassio, BioUltra, ≥99.5% (AT)

B85927

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tert-Butanol, TEBOL^® 99, ≥99.3%

PHR1279

Supelco

(+)- L-ascorbato di sodio, Pharmaceutical Secondary Standard; Certified Reference Material

W287806

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Acido fenilacetico, ≥99%, FCC, FG

900506

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Bicarbonato di sodio, anhydrous, free-flowing, Redi-Dri^™, ReagentPlus^®, ≥99.5%

449962

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Bromuro di potassio, anhydrous, powder, 99.999% trace metals basis

50621

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tert-Butanol, analytical standard

401676

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Bicarbonato di sodio, −40-+140 mesh, ≥95%

451010

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Bromuro di potassio, anhydrous, powder, 99.95% trace metals basis