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Merck

472301

Dimetilsulfóxido

ACS reagent, ≥99.9%

Dimethyl sulfoxide

Sinónimos:

DMSO

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Fórmula lineal:
(CH3)2SO
Número CAS:
Peso molecular:
78.13
Beilstein/REAXYS Number:
506008
EC Number:
MDL number:
UNSPSC Code:
12191502
PubChem Substance ID:
NACRES:
NA.21
Grade:
ACS reagent
Assay:
≥99.9%
Bp:
189 °C (lit.)
Vapor pressure:
0.42 mmHg ( 20 °C)

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grade

ACS reagent

Quality Level

vapor density

2.7 (vs air)

vapor pressure

0.42 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

autoignition temp.

573 °F

expl. lim.

42 %, 63 °F

dilution

(for analytical testing)

impurities

≤0.001 meq/g Titr. acid
≤0.1% water

evapn. residue

≤0.01%

color

clear colorless

refractive index

n20/D 1.479 (lit.)

bp

189 °C (lit.)

mp

16-19 °C (lit.)

density

1.10 g/mL (lit.)

SMILES string

CS(C)=O

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

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1 of 4

Este artículo
D5879317275276855
grade

ACS reagent

grade

-

grade

-

grade

anhydrous

assay

≥99.9%

assay

≥99.5%

assay

≥99% (GC)

assay

≥99.9%

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

form

liquid

form

liquid

form

liquid

form

liquid

refractive index

n20/D 1.479 (lit.)

refractive index

n20/D 1.479 (lit.)

refractive index

n20/D 1.479 (lit.)

refractive index

n20/D 1.479 (lit.)

density

1.10 g/mL (lit.)

density

1.10 g/mL (lit.)

density

1.10 g/mL (lit.)

density

1.10 g/mL (lit.)

General description

El dimetil sulfóxido es un organosulfurado, comúnmente utilizado como disolvente polar que puede disolver una amplia variedad de compuestos polares y no polares. También se utiliza como reactivo de reacción en varios procesos bien conocidos, como la oxidación de Swern, la oxidación 2a de Pfitzner-Moffatt, 2b y la reacción de Corey-Chaykovsky [1] [2]
Our premium ACS solvents are ideal for routine chemical synthesis, drying, purification, and critical labware cleaning. They meet or exceed the rigorous standards of the American Chemical Society (ACS), ensuring high-quality results for your research needs.

Premium ACS Solvents: Our solvents meet or exceed the stringent standards set by the American Chemical Society, ensuring high quality and reliability for your laboratory applications.

Replicable and Publishable Results: Designed for consistency, our solvents deliver results that can be reliably reproduced, making them ideal for research that requires publication.

Versatile Applications: Suitable for routine chemical synthesis, drying, purification, and critical labware cleaning, our solvents cater to a wide range of research needs in the laboratory.

Application

El dimetil sulfóxido (DMSO) se ha utilizado:
  • en la preparación de etil 4-[18F]fluorobenzoato.[3]
  • en el medio de cultivo para el ensayo del bromuro del 3-(4,5-dimetiltiazol-2-il)-2,5-difenil-tetrazolio (MTT).[4]
  • como disolvente en síntesis química.
  • para disolver y preparar disoluciones madre de moléculas pequeñas, fármacos y compuestos químicos para diversos ensayos y experimentos.

Other Notes

Si desea información sobre la miscibilidad del dimetilsulfóxido, visite el siguiente enlace:
Tabla de miscibilidad/inmiscibilidad del dimetilsulfóxido

Disclaimer

Fácilmente superenfriado, vuelve a fundir lentamente a temperatura ambiente. Producto solidificado que puede volver a licuarse por calentamiento a temperatura ambiente sin detrimento del producto.

Clase de almacenamiento

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup


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The applications of dimethyl sulfoxide as reagent in organic synthesis
Xiao-Feng W, et al.
Advanced Synthesis & Catalysis, 358, 336-352 (2016)
Dimethyl sulfoxide extraction method for the liquid chromatographic analysis of microencapsulated vitamin D3
Richard P J, et al.
Journal of Agricultural and Food Chemistry, 45, 1784-1786 (1997)
Shuang Hou et al.
Journal of visualized experiments : JoVE, (52)(52), doi:10-doi:10 (2011-07-07)
Biomolecules, including peptides¹⁻⁹, proteins¹⁰⁻¹¹, and antibodies and their engineered fragments¹²⁻¹⁴, are gaining importance as both potential therapeutics and molecular imaging agents. Notably, when labeled with positron-emitting radioisotopes (e.g., Cu-64, Ga-68, or F-18), they can be used as probes for targeted
P Roy et al.
The FEBS journal, 277(2), 441-452 (2009-12-18)
EVI1 is a nuclear zinc finger protein essential to normal development, which participates in acute myeloid leukaemia progression and transforms Rat1 fibroblasts. In this study we show that enforced expression of Evi1 in Rat1 fibroblasts protects from paclitaxel-induced apoptosis, consistent
Oxidation of alcohols by ?activated? dimethyl sulfoxide. A preparative, steric and mechanistic study.
Omura K and Swern D.
Tetrahedron, 34(11), 1651-1660 (1978)

Artículos

Substances are said to be miscible in one another if they dissolve to form a uniform solution. Bookmark or download our miscibility table for common lab solvents.

Se dice que las sustancias son miscibles entre sí si se disuelven hasta formar una disolución uniforme. Marque o descargue nuestra tabla de miscibilidad para los disolventes comunes del laboratorio.

Questions

1–10 of 11 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. I know that this substance is of 2 types, with smell and without smell. What type is this?

    1 answer
    1. This is a high purity DMSO. While odor is not a tested specification, high purity products are expected to be odorless. A disagreeable odor is due to the sulfur moiety in the material. DMSO may also contain small amounts of un-reacted Dimethyl Sulfide (DMS). This DMS is generally contributes to a disagreeable odor.

      Helpful?

  4. Can I use this DMSO for cell freezing?Is it sterile

    1 answer
    1. While DMSO is commonly used as a cryoprotectant in cell freezing, this product has not been tested for use in cell culture. This product is also not sterile. See the links below to review the sterile, cell culture tested DMSO product options:
      D2438, DMSO, sterile-filtered, BioPerformance Certified, meets EP & USP testing specifications, suitable for hybridoma
      https://www.sigmaaldrich.com/product/sigma/d2438

      D2650, sterile-filtered, Bioreagent, suitable for hybridoma
      https://www.sigmaaldrich.com/product/sigma/d2650

      Helpful?

  5. Where does DMSO come from?

    1 answer
    1. DMSO is known to have been isolated from tree bark in the past. It is now a commericially synthesized solvent.

      Helpful?

  6. What is the DMSO dissolved in?

    1 answer
    1. DMSO is not dissolved in any solvent. It is a pure chemical compound that is a liquid at room temperature.

      Helpful?

  7. Does DMSO have any synthetic utility?

    1 answer
    1. DMSO has been used to oxidize thiols and disulfides to sulfonic acids, hydrolysis of epoxides, thioalkylation of phenols, and oxidation of primary alcohols and halides, and esters of primary alcohols to aldehydes.

      Helpful?

  8. What is the molarity of DMSO?

    1 answer
    1. DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.

      Helpful?

  9. Is Dimethyl sulfoxide a sterile product?

    1 answer
    1. No, this product is not considered sterile.  Product Nos. D2560 and D2438 are sterile-filtered.

      Helpful?

  10. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

1–10 of 11 Questions  

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