Přejít k obsahu
Merck

Přeskočit na

S4250

D-Serine

≥98% (TLC), suitable for ligand binding assays

Synonyma:

β-Hydroxyalanine, (R)-2-Amino-3-hydroxypropionic acid, Ser

Přihlásit pro zobrazení organizačních a smluvních cen.

Vybrat velikost

Změnit zobrazení
Vám/SKUDostupnostCena
5 g
Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
2 030,00 Kč
25 g
Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.
3 970,00 Kč

O této položce

Empirický vzorec (Hillův zápis):
C3H7NO3
Číslo CAS:
Molekulová hmotnost:
105.09
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
206-229-4
MDL number:
Beilstein/REAXYS Number:
1721403

2 030,00 Kč


Obraťte se na zákaznický servis a vyžádejte si informaci o dostupnosti.

Požádejte o zakázkovou objednávku
Technický servis
Potřebujete pomoc? Náš tým zkušených odborníků je vám k dispozici.
Dovolte nám, abychom vám pomohli


Název produktu

D-Serine, ≥98% (TLC)

Quality Segment

assay

≥98% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

application(s)

cell analysis

SMILES string

N[C@H](CO)C(O)=O

InChI

1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

InChI key

MTCFGRXMJLQNBG-UWTATZPHSA-N

Gene Information

human ... GRIN1(2902)

General description

D-serine is an unusual amino acid expressed in the mammalian brain.
D-serine is a dextro amino acid present in neurons, astrocytes, and microglia. It is synthesized from L-serine by the enzyme serine racemase. Racemase also catalyzes the breakdown of D-serine into ammonia and pyruvate. It is oxidized to hydroxypyruvate by D-amino acid oxidase.

Application

D-serine has been used to prevent glycine-dependent desensitization of N-methyl D-aspartate receptor (NMDAR) and to study its effects on NMDARs to correct behavioral abnormalities in rats after partial sciatic nerve ligation (PSNL).
D-serine has been used as a substrate in D-amino acid oxidase (DAO) activity in human 1321N1 astrocytoma cells. It has also been used in intracerebroventricular administration in rat for the induction of antinociceptive effect.

Biochem/physiol Actions

D-serine is an agonist and glycine mimic which is active at the strychnine-insensitive glycine binding site associated with the N-methyl-D-aspartate (NMDA) receptor as well as the inhibitory post-synaptic glycine receptor. Along with glutamate, it has a role in various physiological processes including synaptic plasticity and receptor transmission. Dysregulation of D-serine signaling has been linked with neurodegenerative diseases and disorders.
D-serine is essential for the normal development of dendrites, neuroblast migration and may have therapeutic potential for treating schizophrenia and depression states. The levels of D-serine is elevated in traumatic brain injury (TBI).

Porovnat podobné položky

Zobrazit úplné porovnání

Zobrazit rozdíly

1 of 1

Tato položka
S5386S43751612506
D-Serine ≥98% (TLC)

Sigma-Aldrich

S4250

D-Serine

DL-Serine BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98% (HPLC)

Sigma-Aldrich

S5386

DL-Serine

DL-Serine ≥98% (TLC)

Sigma-Aldrich

S4375

DL-Serine

L-Serine United States Pharmacopeia (USP) Reference Standard

USP

1612506

L-Serine

description

≥98% (TLC)

description

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98% (HPLC)

description

≥98% (TLC)

description

United States Pharmacopeia (USP) Reference Standard

form

powder

form

powder

form

powder

form

-

technique(s)

ligand binding assay: suitable

technique(s)

cell culture | mammalian: suitable, cell culture | insect: suitable

technique(s)

-

technique(s)

-

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥98% (TLC)

assay

-

color

white to off-white

color

white

color

white

color

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

Gene Information

human ... GRIN1(2902)

Gene Information

-

Gene Information

-

Gene Information

-


Skladovací třída

11 - Combustible Solids

Co se děje?

WGK 3

Bod vzplanutí (°F)

Not applicable

Bod vzplanutí (°C)

Not applicable

PPE (osobní ochranné prostředky)

Eyeshields, Gloves, type N95 (US)



Vyberte jednu z posledních verzí:

Osvědčení o analýze (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Dokumenty section.

Potřebujete-li pomoc, obraťte se na Zákaznická podpora

Již tento produkt vlastníte?

Dokumenty související s produkty, které jste v minulosti zakoupili, byly za účelem usnadnění shromážděny ve vaší Knihovně dokumentů.

Navštívit knihovnu dokumentů




Questions

1–9 of 9 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What is the reason your D-Serine is not suitable for human consumption? Do you know from where suitable for human consumption D-Serine can be sourced?

    1 answer
    1. The products that we sell are for research use only, they should not be used in humans.

      Helpful?

  4. Can D-Serine, Product No. S4250, be autoclaved?

    1 answer
    1. Yes, solutions of this product can be autoclaved.

      Helpful?

  5. What is the melting point for S4250, D-Serine?

    1 answer
    1. The melting point for this product is 228°C.

      Helpful?

  6. How does the storage temperature relate to shipping conditions?

    1 answer
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Helpful?

  7. Is Product S4250, D-Serine, suitable for human consumption?

    1 answer
    1. This product is not suitable for human consumption.  This product is intended primarily for laboratory research purposes and should not be used for any other purposes, including but not limited to, in vitro diagnostic purposes, in foods, drugs, medical devices, or cosmetics for humans or animals, or for other commercial purposes.

      Helpful?

  8. What is the solubility of Product S4250, D-Serine?

    1 answer
    1. This product is soluble in water at a concentration of 50mg/mL. It is also soluble in 1M hydrochloric acid.  It is not soluble in ethanol or ether.

      Helpful?

  9. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

Reviews

No rating value

Active Filters