N-076

4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanon (NNK) -Lösung

Name: 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanon (NNK) -Lösung
Brand: CERILLIAN
Price: 143 EUR
Availability: InStock

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

Synonym(e):

4-(Methylnitrosoamino)-1-(3-pyridinyl)-1-butanon, 4-(Methylnitrosamino)-1-(3-pyridinyl)-1-butanon, NNK

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Empirische Formel (Hill-System):

C₁₀H₁₃N₃O₂

CAS-Nummer:

64091-91-4

Molekulargewicht:

207.23

NACRES:

NA.24

PubChem Substance ID:

329818458

UNSPSC Code:

41116107

MDL number:

MFCD00274580

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Produktname

4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanon (NNK) -Lösung, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

InChI

1S/C10H13N3O2/c1-13(12-15)7-3-5-10(14)9-4-2-6-11-8-9/h2,4,6,8H,3,5,7H2,1H3

SMILES string

CN(CCCC(=O)c1cccnc1)N=O

InChI key

FLAQQSHRLBFIEZ-UHFFFAOYSA-N

grade

certified reference material

form

liquid

feature

Snap-N-Spike^®/Snap-N-Shoot^®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant^®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

Quality Level

300

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Dieser Artikel	N-075	N-077	75283
Supelco N-076 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanon (NNK) -Lösung	Supelco N-075 (±)-N′-Nitrosonornicotine (NNN) solution	Supelco N-077 (S)-N-Nitrosoanabasine (NAB) solution	Supelco 75283 N-Nitrosoanabasin
application(s) forensics and toxicology	application(s) forensics and toxicology	application(s) forensics and toxicology	application(s) cleaning products cosmetics food and beverages personal care
technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable, solid phase extraction (SPE): suitable
form liquid	form liquid	form liquid	form -
Quality Level 300	Quality Level 300	Quality Level 300	Quality Level 100
grade certified reference material	grade certified reference material	grade certified reference material	grade analytical standard
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C

General description

Certified Spiking Solutions^® are suitable for use in nicotine testing, environmental monitoring, or clinical and diagnostic testing of nicotine biomarkers by LC-MS/MS or GC/MS. Also known as nicotine-derived nitrosamine ketone, NNK is a potent carcinogen and biomarker of exposure to cigarette smoke. NNK, produced upon the curing of tobacco, is found in a variety of tobacco products including chewing tobacco, snuff, cigarettes, and cigars.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

A-097

(+)-Anabasine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

A-100

Anabasine-d₄ hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

C-016

(−)-Cotinine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

C-017

(+/-)-Cotinin-d₃ -Lösung, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

C-035

(±)-Cotinin-d₃ -Lösung, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

N-008

S(−)-Nikotin -Lösung, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

N-048

(±)-Nicotine-d₄ solution, 100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

N-071

(±)-Nornicotine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

N-072

(±)-Nornicotine-d₄, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

N-075

(±)-N′-Nitrosonornicotine (NNN) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

N-077

(S)-N-Nitrosoanabasine (NAB) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

pictograms

GHS02,GHS06,GHS08

signalword

Danger

hcodes

H225,H301 + H311 + H331,H370

pcodes

P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Lagerklasse

3 - Flammable liquids

wgk

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK.

Lucie Skarydova et al.

Drug metabolism letters, 6(3), 174-181 (2013-01-22)

Tobacco smoking is the most widely known cause of human cancer-related death worldwide. NNK is one of the proved human carcinogens contributing to the development of several types of cancer. The carcinogenic effect of NNK depends on the metabolic pathway.

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma.

Chi-Jung Chung et al.

Toxicology letters, 216(1), 16-22 (2012-11-13)

Gene polymorphisms of the 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes-cytochrome P450 (CYP) monooxygenase 2A13 (CYP2A13) and UDP-glucuronosyltransferases (UGT)-2B7 could contribute to the levels of NNK-related metabolites in urine, thereby increasing the susceptibility to urothelial carcinoma (UC). Therefore, our study aimed to evaluate

Nicotine and gastrointestinal disorders: its role in ulceration and cancer development.

Kent-Man Chu et al.

Current pharmaceutical design, 19(1), 5-10 (2012-09-07)

Cigarette smoke has always been the single most preventive cause of death in the world. In 2011, over 460,000 died from cigarette smoke-related diseases in US. The detrimental effects of cigarette smoke on human beings are due to the presence

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) regulates CTL activation and memory programming.

Zhifeng Sun et al.

Biochemical and biophysical research communications, 435(3), 472-476 (2013-05-16)

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the major carcinogens in tobacco. NNK has been associated with various cancers in tobacco users, especially lung cancer. However, the effects of NNK on cytotoxic T lymphocytes (CTLs), the cells responsible for destrcution of maligant

The tobacco carcinogen nitrosamine induces a differential gene expression response in tumour susceptible A/J and resistant C3H mouse lungs.

William Gordon et al.

European journal of cancer (Oxford, England : 1990), 49(3), 725-733 (2012-09-27)

The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), an important carcinogen found in tobacco products, causes lung cancer in genetically susceptible animals. In addition to mutations of the K-Ras gene, NNK has non-mutagenic effects that include alterations in gene expression and immunomodulation in the

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