MABF144B

Anti-KLRG1 (mouse), violetFluor^® 450, clone 2F1 Antibody

clone 2F1, from hamster(Syrian), violetFluor^® 450

• Synonym(e): Killer cell lectin-like receptor subfamily G member 1, Mast cell function-associated antigen 2F1, KLRG1
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: hamster (Syrian)
• Qualitätsniveau: 100
• Konjugat: violetFluor^® 450
• Antikörperform: purified antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: 2F1, monoclonal
• Speziesreaktivität: mouse
• Verpackung: antibody small pack of 25 μg
• Methode(n): flow cytometry: suitable
• Isotyp: IgG
• UniProt-Hinterlegungsnummer: O88713
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: mouse ... Klrg1(50928)

Beschreibung

Allgemeine Beschreibung

The 2F1 antibody reacts with mouse KLRG1 (Killer cell Lectin-like Receptor G1). This 30-38 kDa homodimeric receptor may be expressed by activated, mature NK cells and by effector/memory T cells, with potentially different roles in each cell type. KLRG1 can regulate, in an inhibitory fashion, the development and effector functions of NK cells, and is often cited as a senescence or terminal differentiation marker for T cells. Ligands for KLRG1 include members of the cadherin family of adhesion molecules, specifically N-Cadherin, E-Cadherin, and R-Cadherin. These interactions may induce bidirectional, immunosuppressive signaling in both KLRG- and Cadherin-expressing cells. A more recently identified role for KLRG1-Cadherin signaling in tissue organization, e.g. in cardiac angiogenesis, expands the function of these interactions beyond immunosuppression of immune cells. (Bouchentouf et al. 2010. J. Immunol. 185: 7014-7025).

Immunogen

Immunogen information for this antibody is proprietary information.

Anwendung

Research Category
Entzündung & Immunologie

Research Sub Category
Immunoglobuline & Immunologie

Anti-KLRG1 (mouse), violetFluor^® 450, clone 2F1 Antibody is an antibody against KLRG1 for use in Flow Cytometry.

Physikalische Form

Purified by size-exclusion chromatography

Purified Golden Syrian Hamster monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.

Angaben zur Herstellung

Stable for 1 year at 2-8°C from date of receipt.
Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Hinweis zur Analyse

This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 μg from a representative lot detected KLRG1 in one million C57Bl/6 splenocytes stained with PE Anti-mouse NK1.1.

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

Rechtliche Hinweise

violetFluor is a registered trademark of Tonbo Biotechnologies

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable