D6500

2′-Desoxyadenosin-5′-Triphosphat Dinatriumsalz

≥97%

• Synonym(e): dATP
• Empirische Formel (Hill-System): C₁₀H₁₄N₅Na₂O₁₂P₃
• CAS-Nummer: 74299-50-6
• Molekulargewicht: 535.15
• PubChem Substance ID: 24894029
• eCl@ss: 32160414
• UNSPSC Code: 41106305
• NACRES: NA.51
• EC Number: 277-809-2
• MDL number: MFCD00080335

Eigenschaften

• Produktname: 2′-Desoxyadenosin-5′-Triphosphat Dinatriumsalz, ≥97%
• InChI key: JEKDCIBJADJZSK-LNUHRGGJSA-L
• InChI: 1S/C10H16N5O12P3.2Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;/q;2*+1/p-2/t5-,6+,7?;;/m0../s1
• SMILES string: [Na+].[Na+].Nc1ncnc2n(cnc12)C3C[C@H](O)[C@@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)O3
• biological source: natural (inorganic)
• assay: ≥97%
• form: powder
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• Quality Level: 200

Beschreibung

Application

2′-Deoxyadenosine 5′-triphosphate (dATP) is used as a substrate by a variety of polymerases including DNA polymerase(s) and reverse transcriptase(s).

2′-Deoxyadenosine 5′-triphosphate disodium salt has been used:

• for Smac- X-linked inhibitor of apoptosis protein (Smac-XIAP) binding assay.[1]
• as a component of polymerase chain reaction (PCR) using AM-toxin primers.[2]
• to determine the affinity constant (Kd) with the transcription termination factor Rho.[3]
• to determine the activity of poly ADP-ribose polymerase 1 (PAPR-1 ).[4]

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)