G1001

D-Glutaminsäure

Name: <SC>D</SC>-Glutaminsäure
Brand: SIGMA

≥99% (TLC), suitable for ligand binding assays

Synonym(e):

(R)-2-Amino-glutarsäure, (R)-2-Aminopentandisäure, D-Glu, R-(−)-1-Aminopropan-1,3-dicarbonsäure

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Lineare Formel:

HO₂CCH₂CH₂CH(NH₂)CO₂H

CAS-Nummer:

6893-26-1

Molekulargewicht:

147.13

NACRES:

NA.32

PubChem Substance ID:

24895031

UNSPSC Code:

12352209

EC Number:

230-000-8

MDL number:

MFCD00063112

Beilstein/REAXYS Number:

1723800

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Produktname

D-Glutaminsäure, ≥99% (TLC)

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1

InChI key

WHUUTDBJXJRKMK-GSVOUGTGSA-N

SMILES string

N[C@H](CCC(O)=O)C(O)=O

assay

≥99% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

mp

200-202 °C (subl.) (lit.)

Quality Level

200

Gene Information

human ... CCR2(1231)

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Dieser Artikel	1.00291	G0355000	W328502
Sigma-Aldrich G1001 D-Glutaminsäure	Millipore 1.00291 L-Glutaminsäure	G0355000 Glutaminsäure	Sigma-Aldrich W328502 L-Glutaminsäure
form powder	form solid	form -	form powder or crystals
assay ≥99% (TLC)	assay ≥99% substance (anhydrous) basis (alkalimetric)	assay -	assay 98.5-101.5% dry basis (perchloric acid titration)
technique(s) ligand binding assay: suitable	technique(s) -	technique(s) -	technique(s) -
mp 200-202 °C (subl.) (lit.)	mp 160 °C	mp 205 °C (dec.) (lit.)	mp 205 °C (dec.) (lit.)
Quality Level 200	Quality Level 100	Quality Level -	Quality Level 400
color white to off-white	color -	color -	color -

Biochem/physiol Actions

unnatürliches Glutaminsäure-Isomer

Application

D-glutamic acid is suitable for use in the structure-affinity relationship (SAR)-study of GR (glutamate racemase) enzyme and its inhibitors.[1]

General description

D-Glutamic acid is an essential constituent of the bacterial peptidoglycan structure. It is added to UDP-N-acetylmuramyl-L-alanine (UDP-MurNAc-L-alanine) by the enzyme D-glutamic acid-adding enzyme (murD). This is, then, incorporated into the peptidoglycan precursor.[2] Peptidoglycan makes up the cell walls of Gram-positive and -negative bacteria. The conversion of L-glutamate to D-glutamate by glutamate racemase (GR) enzyme is an essential step in the synthesis of peptidoglycan.[1]

Lagerklasse

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Analysenzertifikate (COA)

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Allosteric control of an ionotropic glutamate receptor with an optical switch.

Matthew Volgraf et al.

Nature chemical biology, 2(1), 47-52 (2006-01-13)

The precise regulation of protein activity is fundamental to life. The allosteric control of an active site by a remote regulatory binding site is a mechanism of regulation found across protein classes, from enzymes to motors to signaling proteins. We

Identification of the Escherichia coli murI gene, which is required for the biosynthesis of D-glutamic acid, a specific component of bacterial peptidoglycan.

P Doublet et al.

Journal of bacteriology, 174(18), 5772-5779 (1992-09-01)

The murI gene of Escherichia coli, whose inactivation results in the inability to form colonies in the absence of D-glutamic acid, was identified in the 90-min region of the chromosome. The complementation of an auxotrophic E. coli B/r strain by

Hybrid Steered Molecular Dynamics-Docking: An Efficient Solution to the Problem of Ranking Inhibitor Affinities Against a Flexible Drug Target.

Katie L Whalen et al.

Molecular informatics, 30(5), 459-471 (2011-07-09)

Existing techniques which attempt to predict the affinity of protein-ligand interactions have demonstrated a direct relationship between computational cost and prediction accuracy. We present here the first application of a hybrid ensemble docking and steered molecular dynamics scheme (with a

A descending dopamine pathway conserved from basal vertebrates to mammals.

Dimitri Ryczko et al.

Proceedings of the National Academy of Sciences of the United States of America, 113(17), E2440-E2449 (2016-04-14)

Dopamine neurons are classically known to modulate locomotion indirectly through ascending projections to the basal ganglia that project down to brainstem locomotor networks. Their loss in Parkinson's disease is devastating. In lampreys, we recently showed that brainstem networks also receive

Subthalamic GAD gene therapy in a Parkinson's disease rat model.

Jia Luo et al.

Science (New York, N.Y.), 298(5592), 425-429 (2002-10-12)

The motor abnormalities of Parkinson's disease (PD) are caused by alterations in basal ganglia network activity, including disinhibition of the subthalamic nucleus (STN), and excessive activity of the major output nuclei. Using adeno-associated viral vector-mediated somatic cell gene transfer, we

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Anonym

vor 6 Monaten

How can I determine the shelf life / expiration / retest date of this product?

1 Antwort
1. Technical Support
  
  vor 6 Monaten
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
  
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Anonym

vor 10 Monaten

How is shipping temperature determined? And how is it related to the product storage temperature?

1 Antwort
1. Technical Support
  
  vor 10 Monaten
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
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