E9505

β-Estradiol 3-sulfate sodium salt

≥93%

• Sinonimo/i: 1,3,5(10)-Estratriene-3,17β-diol 3-sulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-sulfate
• Formula condensata: C₁₈H₂₃O₅SNa
• Numero CAS: 4999-79-5
• Peso molecolare: 374.43
• NACRES: NA.77
• PubChem Substance ID: 24894699
• UNSPSC Code: 51111800
• MDL number: MFCD00056553
• Assay: ≥93%
• Form: powder

Proprietà

• sterility: non-sterile
• Quality Segment: 200
• assay: ≥93%
• form: powder
• contains: ~70% N-methyl-D-glucamine as stabilizer
• solubility: methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [Na].[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24
• InChI: 1S/C18H24O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,17+,18+;;/m1../s1
• InChI key: PYPVMTJYMKHIST-LBARCDFESA-N

Descrizione

General description

β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women.

Application

β-Estradiol 3-sulfate sodium salt has been used to measure the estradiol level from culture supernatant in ultra-performance liquid chromatography-tandem mass spectrometry.

Biochem/physiol Actions

β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity. β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy. 17-β-Estradiol is the most active estrogen generated in our body. During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.

Packaging

Package size based on steroid content

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Parola di avvertenza: Warning
• Codici di pericolo: H302 + H332,H351
• Avvertenze di sicurezza: P202 - P261 - P264 - P301 + P312 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
• Classe di stoccaggio: 11 - Combustible Solids
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable
• DPI (dispositivi di protezione individuale): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges