1316004

Hydrocortisone

United States Pharmacopeia (USP) Reference Standard

• Sinonimo/i: 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
• Formula empirica (notazione di Hill): C₂₁H₃₀O₅
• Numero CAS: 50-23-7
• Peso molecolare: 362.46
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750063
• MDL number: MFCD00011654
• Beilstein/REAXYS Number: 1354819

Proprietà

• grade: pharmaceutical primary standard
• agency: USP
• API family: hydrocortisone
• manufacturer/tradename: USP
• mp: 211-214 °C (lit.)
• application(s): pharmaceutical; pharmaceutical (small molecule)
• format: neat
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
• InChI: 1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: JYGXADMDTFJGBT-VWUMJDOOSA-N
• Gene Information: human ... NR3C1(2908)

Descrizione

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrocortisone USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard stock, standard, and system suitability solution for assay, identification, and performance test by liquid chromatography in accordance with the given below monographs of United States Pharmacopeia (USP) :

• Hydrocortisone Sodium Succinate for Injection
• Hydrocortisone Tablets
• Hydrocortisone Gel
• Hydrocortisone Lotion

Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex.

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na²⁺ retention potency.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Parola di avvertenza: Danger
• Codici di pericolo: H360Df,H373
• Avvertenze di sicurezza: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1A - STOT RE 2
• Classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable
• Organi bersaglio: Adrenal gland,Bone marrow