Passa al contenuto
Merck

Fatal kavalactone intoxication by suicidal intravenous injection.

Forensic science international (2015-02-17)
Raimo A Ketola, Jenni Viinamäki, Ilpo Rasanen, Anna Pelander, Sirkka Goebeler
ABSTRACT

Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxiolytic and sedative properties. Sales of kava extracts were severely restricted or prohibited in European countries in 2002 following several cases of serious hepatotoxicity. Here we report a case where high concentrations of kavalactones and ethanol were detected in post mortem femoral blood. An injection needle with a 10-mL syringe containing 7.5 mL of slightly yellowish liquid was found next to the victim, and there were numerous needle prints on both lower arms following the venous tracks. No evidence of other cause of death was found in the medico-legal investigation. The case was therefore classified as suicide using an injection of kavalactones intravenously together with alcohol poisoning.

MATERIALI
Numero di prodotto
Marchio
Descrizione del prodotto

Sigma-Aldrich
Metanolo, suitable for HPLC, ≥99.9%
Sigma-Aldrich
Acido trifluoroacetico, ReagentPlus®, 99%
Sigma-Aldrich
Metanolo, ACS reagent, ≥99.8%
Sigma-Aldrich
Acido trifluoroacetico, suitable for HPLC, ≥99.0%
Sigma-Aldrich
Trizma® base, Primary Standard and Buffer, ≥99.9% (titration), crystalline
Sigma-Aldrich
Metanolo, HPLC Plus, ≥99.9%
Sigma-Aldrich
Acido trifluoroacetico, puriss. p.a., suitable for HPLC, ≥99.0% (GC)
Sigma-Aldrich
Trizma® base, BioPerformance Certified, meets EP, USP testing specifications, suitable for cell culture, ≥99.9% (titration)
Supelco
Caffeina, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Metanolo, Laboratory Reagent, ≥99.6%
Sigma-Aldrich
Metanolo, suitable for HPLC, gradient grade, suitable as ACS-grade LC reagent, ≥99.9%
Supelco
N-metil-N-(trimetilsilil)trifluoroacetammide, derivatization grade (GC derivatization), LiChropur, ≥98.5%
Sigma-Aldrich
Chlorotrimethylsilane, ≥98.0% (GC)
Sigma-Aldrich
Tromethamine, meets USP testing specifications
Sigma-Aldrich
Caffeina, powder, ReagentPlus®
Sigma-Aldrich
Tris(idrossimetil)aminometano, ACS reagent, ≥99.8%
Sigma-Aldrich
Acido trifluoroacetico, ≥99%, for protein sequencing
Sigma-Aldrich
Sigma 7-9®, ≥99% (titration), powder or crystals
Sigma-Aldrich
Metanolo, ACS spectrophotometric grade, ≥99.9%
Sigma-Aldrich
Trizma® base, BioUltra, Molecular Biology, ≥99.8% (T)
Sigma-Aldrich
Metanolo, ACS reagent, ≥99.8%
Sigma-Aldrich
Salicylic acid, ACS reagent, ≥99.0%
Supelco
N-metil-N-(trimetilsilil)trifluoroacetammide, synthesis grade
Sigma-Aldrich
Chlorotrimethylsilane, purified by redistillation, ≥99%
Sigma-Aldrich
Metanolo, Absolute - Acetone free
Supelco
Salicylic acid, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Caffeina, anhydrous, 99%, FCC, FG
USP
Metanolo, United States Pharmacopeia (USP) Reference Standard
Sigma-Aldrich
Metanolo, BioReagent, ≥99.93%
Supelco
N-metil-N-(trimetilsilil)trifluoroacetammide, BioReagent, for silylations, LiChropur