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Effect of gold nanoparticles on photodynamic efficiency of 5-aminolevolenic acid photosensitiser in epidermal carcinoma cell line: an in vitro study.

Effect of gold nanoparticles on photodynamic efficiency of 5-aminolevolenic acid photosensitiser in epidermal carcinoma cell line: an in vitro study.

IET nanobiotechnology (2013-11-12)

Seyed Mohammad Amini, Sharmin Kharrazi, Mahnaz Hadizadeh, Mohsen Fateh, Reza Saber

要旨

In the recent years, enhanced functionality of treatment systems based on nanostructures has attracted a lot of interest. Photodynamic therapy (PDT) is one such treatment method. Here, the authors report the results of the investigations on synthesis and characterisation of gold nanoparticles (GNPs) and their application in PDT along with 5-aminolevolenic acid (5-ALA) (as photosensitiser) with no conjugation. Three sizes of GNPs were synthesised and their cytotoxicity was investigated by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on epidermal carcinoma cell line. The results showed that the PDT efficiency of ALA increased in presence of GNPs. This effect was more considerable for 4 nm particles.

材料

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ブランド

製品内容

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チアゾリルブルーテトラゾリウムブロミド, 98%

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チアゾリルブルーテトラゾリウムブロミド, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97.5% (HPLC)

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金被覆顕微鏡用スライドガラス, layer thickness 100 Å, 99.999% (Au)

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金, wire, diam. 0.25 mm, ≥99.9% trace metals basis

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金, wire, diam. 0.1 mm, 99.99% trace metals basis

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金被覆ガラスカバースリップ, layer thickness 100 Å, 99.999% (Au), L × W × thickness 22 mm × 22 mm × 130-170 μm, square

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