1.37171

Polysorbate 80

high purity, EMPROVE^® EXPERT, Ph. Eur., ChP, JP, NF

• 동의어(들): TWEEN^® 80, POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80
• CAS 번호: 9005-65-6
• MDL number: MFCD00082107
• UNSPSC 코드: 12352207
• EC 인덱스 번호: 500-019-9

속성

• 생물학적 소스: synthetic
• Quality Level: 500
• Grade: GMP; Halal; Kosher
• Agency: ChP; JP; NF; Ph. Eur.
• 설명: GMO free; low in endotoxins
• 제품 라인: EMPROVE^® EXPERT
• 양식: liquid
• 효능: 42200 mg/kg LD₅₀, oral
• 분자량: 1310 g/mol
• 불순물: endotoxins, low
• pH: 5-7 (20 °C, 50 g/L)
• bp: >100 °C
• density: 1.07 g/cm³ at 25 °C
• 응용 분야: liquid formulation; parenterals; pharmaceutical; solubility enhancement
• 외래 활성: Aflatoxin free
• 저장 온도: 15-25°C
• SMILES string: CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO
• InChI: 1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+
• InChI key: RGPBUVUVZKQNHD-MDZDMXLPSA-N

설명

일반 설명

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

애플리케이션

Polysorbate 80 is used to stabilize biomolecule formulations and as solubilizer, emulsifier and wetting agent in small molecule formulations. Polysorbates are known to degrade via autoxidation and hydrolysis. Degradation products can have a negative impact on the stability of the protein as well as the small molecule API. To reduce this risk, the polysorbate high-purity grade contains a low amount of impurities, especially peroxide.

Intended for high-risk applications, this Emprove^® Expert grade contains bioburden and endotoxin limits.

포장

1371710100 / 100ml / glass bottle
1371711000 / 1L / glass bottle

법적 정보

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

TWEEN is a registered trademark of Croda International PLC

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): 235.4 °F - closed cup
• Flash Point (°C): > 113 °C - closed cup