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Merck

C3000000

Vitamina B12

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

α-(5,6-Dimetilbencimidazolil)cianocobamida, CN-Cbl, Cianocob(III)alamina, Cianocobalamina

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20 MG

MXP 4,124.00

MXP 4,124.00


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Fórmula empírica (notación de Hill):
C63H88CoN14O14P
Número CAS:
Peso molecular:
1355.37
Beilstein/REAXYS Number:
4122889
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

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biological source

synthetic

grade

pharmaceutical primary standard

agency

EP

API family

cyanocobalamin

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

>300 °C (decomposes before melting)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

Inchi Key

RMRCNWBMXRMIRW-QJRSUKKJSA-L

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Este artículo
PHR1234C3607Y0002204
technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

format

neat

format

neat

format

-

format

-

form

solid

form

-

form

powder

form

-

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

-

grade

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Cyanocobalamin, a B vitamin with potential applications in medical and food industries, is vital to growth, cell reproduction, hematopoiesis, etc. It is utilized for the management of trigeminal neuralgia and multiple sclerosis.[1][2][3]

Application

Cyanocobalamin may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.[1][4][5][6][7]

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

comparable product

related product

Referencia del producto
Descripción
Precios

Clase de almacenamiento

11 - Combustible Solids

wgk_germany

WGK 1


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Visite la Librería de documentos

LC simultaneous determination of Thioctic Acid, Benfotiamine and Cyanocobalamin in Thiotacid Compound capsules
Salem H
Chromatographia, 72(3-4), 327-330 (2010)
Microbial production of vitamin B 12: a review and future perspectives
Fang, Huan and Kang, Jie and Zhang, Dawei
Microbial cell factories, 16(1), 15-15 (2017)
Cyanocobalamin
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 16(1), 2178-2179 (2014)
Ultra-high performance liquid chromatographic and mass spectrometric analysis of active vitamin B12 in cells of Propionibacterium and fermented cereal matrices.
Chamlagain B, Edelmann M, Kariluoto S, et al.
Inflammation and regeneration, 166, 630-638 (2014)
A rapid determination of the relative purity of vitamin B12 (Cyanocobalamin) in pharmaceutical products
Bruening CF, et al.
Journal of the American Pharmaceutical Association, 47(1), 15-20 (1958)

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