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Merck

A4562

5-(N,N-Dimethyl)amiloride hydrochloride

cAMP-dependent protein kinase inhibitor, powder

Sinónimos:

3-Amino-N-(aminoiminoethyl)-5-(dimethylamino)-6-chloropyrazinecarboxamide hydrochloride, DMA

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25 MG

MXP 5,178.00

100 MG

MXP 17,112.00

MXP 5,178.00

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Fórmula empírica (notación de Hill):
C8H12ClN7O · HCl
Número CAS:
1214-79-5
Peso molecular:
294.14
UNSPSC Code:
12352200
PubChem Substance ID:
24278216
NACRES:
NA.77
MDL number:
MFCD00069207

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Nombre del producto

5-(N,N-Dimethyl)amiloride hydrochloride,

SMILES string

Cl.CN(C)c1nc(N)c(nc1Cl)C(=O)\N=C(\N)N

InChI key

IIUPTHVVXMBJMQ-UHFFFAOYSA-N

InChI

1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H

form

powder

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784)

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1 of 4

Este artículo
A7410SML0574M9656
5-(N,N-Dimethyl)amiloride hydrochloride

Sigma-Aldrich

A4562

5-(N,N-Dimethyl)amiloride hydrochloride

Amiloride hydrochloride hydrate ≥98% (HPLC), powder

Sigma-Aldrich

A7410

Amiloride hydrochloride hydrate

YM-298198 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0574

YM-298198 hydrochloride

H-8 dihydrochloride >98% (HPLC)

Sigma-Aldrich

M9656

H-8 dihydrochloride

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784)

Gene Information

human ... ABP1(26), ACCN1(40), ACCN2(41), PLAU(5328), SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), TNF(7124)
mouse ... Abp1(76507), Accn1(11418), Accn2(11419), Plau(18792), Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278), Slc9a1(20544)
rat ... Abp1(65029), Accn1(25364), Accn2(79123), Plau(25619), Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782)

Gene Information

-

Gene Information

human ... CALCRL(10203), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
rat ... Calcrl(25029)

Application

5-(N,N-Dimethyl)amiloride hydrochloride is a selective blocker of Na2/H+ antiport. 5-(N,N-Dimethyl)amiloride hydrochloride has been investigated for its ability to reduce inflammatory pain.

Biochem/physiol Actions

Selective blocker of Na+/H+ antiport; IC50 = 6.9 μM.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000299621
0000299622
0000299622
0000299621
0000259562

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Product Information Sheet - A4562

Product Information Sheet

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