D3759

Sigma-Aldrich

Dextran from Leuconostoc mesenteroides

average mol wt 48,000-90,000

Fórmula lineal:
(C6H10O5)n
Número de CAS:
EC Number:
MDL number:
NACRES:
NA.25

Quality Level

biological source

bacterial (Leuconostoc mesenteroides)

form

powder

optical activity

[α]/D 199°

mol wt

average mol wt 48,000-90,000

solubility

H2O: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

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Application

Dextrans are used in many applications as platelet aggregants, plasma volume extenders, osmotic pressure regulators, stabilizers, organ separation media, matrix components, copolymers, microcarriers, binding agents, viscosity modifiers, antithrombotics, lubricants and physical structure components. They may be used as long hydrophilic spacer arms to improve the performance (freedom of movement) of conjugated/bound proteins. Dextrans may be derivatized for use in biosensor systems.
Dextrans of less than 60,000Da are generally considered low molecular weight dextrans. Low molecular weight dextrans are often preferred versus high molecular weight dextrans due to their viscosities, aggregation and permeation properties. High molecular weight, water-soluble, dextran polymers have been used in a wide variety of biomedical applications. Dextran (48,000-90,000) may be used to induce blood aggregation and as a viscosity plasma expander (HVPE).
Use of dextrans as long and hydrophilic spacer arms improves the performance of immobilized proteins acting on macromolecules.

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 2

Flash Point F

Not applicable

Flash Point C

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificado de Análisis

Certificado de origen

Leena Pitkänen et al.
Investigative ophthalmology & visual science, 46(2), 641-646 (2005-01-27)
To determine the effects of solute molecular weight and lipophilicity on the permeability of a retinal pigment epithelium (RPE)-choroid preparation. Fresh RPE-choroid specimens from bovine eyes were placed in diffusion chambers for permeability experiments with carboxyfluorescein, fluorescein isothiocyanate (FITC)-labeled dextrans...
Sahitya Katikaneni et al.
Bioanalysis, 3(21), 2419-2426 (2011-11-15)
The purpose of this study was to optimize parameters pertaining to microdialysis technique so as to make this method feasible for evaluating transdermal transport of macromolecules. Microdialysis experiments were performed in vivo using hairless rats with daniplestim as the model...
Andreas M A O Pollet et al.
Micromachines, 11(1) (2020-01-08)
The vasculature plays a central role as the highway of the body, through which nutrients and oxygen as well as biochemical factors and signals are distributed by blood flow. Therefore, understanding the flow and distribution of particles inside the vasculature...
Diego Delgado et al.
Human gene therapy, 23(4), 345-355 (2012-02-03)
The goal of the present study was to analyze the potential application of nonviral vectors based on solid lipid nanoparticles (SLN) for the treatment of ocular diseases by gene therapy, specifically X-linked juvenile retinoschisis (XLRS). Vectors were prepared with SLN...
Yuichi Ozaki et al.
Circulation journal : official journal of the Japanese Circulation Society, 76(4), 922-927 (2012-02-04)
Although an intracoronary frequency-domain optical coherence tomography (FD-OCT) system overcomes several limitations of the time-domain OCT (TD-OCT) system, the former requires injection of contrast media for image acquisition. The increased total amount of contrast media for FD-OCT image acquisition may...
Protocolos
Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(1-6) linkages. The remaining a(1-3) linkages account for the branching of dextran. Conflicting data on the branch lengths implies that the average branch length is less than three glucose units. However, other methods indicate branches of greater than 50 glucose units exist.
Más información
Contenido relacionado
Learn about C6H10O6 or dextran formation, classes and naming from MilliporeSigma. Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, which have a linear backbone of α-linked d-glucopyranosyl repeating units.
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