Saltar al contenido
Merck

M6133

7-Methylguanosine 5′-triphosphate sodium salt

≥85% (HPLC), natural (inorganic), powder

Sinónimos:

m7GTP

Slide 1 of 1
Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

5 MG

MXP 4,219.00

10 MG

MXP 7,269.00

25 MG

MXP 14,536.00

MXP 4,219.00

Comprobar disponibilidad del carrito
Solicite una orden a granel

Acerca de este artículo

Fórmula empírica (notación de Hill):
C11H18N5O14P3 · xNa+
Número CAS:
104809-18-9
Peso molecular:
537.21 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
24897079
NACRES:
NA.51
MDL number:
MFCD00063376

Documentos clave

Ver Toda la documentación

Saltar a

Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarle

Nombre del producto

7-Methylguanosine 5′-triphosphate sodium salt, ≥85% (HPLC)

SMILES string

[Na+].C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3N=C(N)NC([O-])c13

InChI

1S/C11H20N5O14P3.Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22;/h3-4,6-7,9-10,17-18H,2H2,1H3,(H,23,24)(H,25,26)(H3,12,13,14)(H2,20,21,22);/q;+1/p-1/t4-,6-,7-,9?,10-;/m1./s1

InChI key

FSMRTZAMTMQMEF-OCMBMSOASA-M

biological source

natural (inorganic)

assay

≥85% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless to faint yellow or tan

storage temp.

−20°C

Quality Level

200

Categorías relacionadas

Comparar elementos similares

Ver comparación completa

Mostrar Diferencias

1 of 4

Este artículo
M3509M5883D7409
7-Methylguanosine 5′-triphosphate sodium salt ≥85% (HPLC)

Sigma-Aldrich

M6133

7-Methylguanosine 5′-triphosphate sodium salt

β,γ-Methyleneguanosine 5′-triphosphate sodium salt ≥98% (HPLC)

Sigma-Aldrich

M3509

β,γ-Methyleneguanosine 5′-triphosphate sodium salt

7-Methylguanosine 5′-diphosphate sodium salt ≥92.5%

Sigma-Aldrich

M5883

7-Methylguanosine 5′-diphosphate sodium salt

2′,3′-Dideoxyguanosine 5′-triphosphate sodium salt ≥90% (HPLC)

Sigma-Aldrich

D7409

2′,3′-Dideoxyguanosine 5′-triphosphate sodium salt

biological source

natural (inorganic)

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

form

powder

form

powder

form

powder

form

powder

assay

≥85% (HPLC)

assay

≥98% (HPLC)

assay

≥92.5%

assay

≥90% (HPLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Application

7-Methylguanosine 5′-triphosphate (m7GTP) is use to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis. m7GTP may be used to create affinity media for capture and purification of molecules such as eukaryotic initiation factor eIF4E.
7-Methylguanosine 5′-triphosphate sodium salt has been used to test its affinity towards Poly(A)-specific ribonuclease (PARN) polypeptides using fluorescence titrations.[1] It has also been used in crystallization along with gemin5 fragment (G5N)[2] and DM15 region of human La-related 15 protein 1 ( LARP1).[3]

Biochem/physiol Actions

7-Methylguanosine 5′-triphosphate (m7GTP) inhibits in vitro protein synthesis by binding to translation initiation complexes.[4] m7GTP is useful to study the structures and mechanisms of eukaryotic cellular mRNA caps in the context of mRNA involvement in protein synthesis.[5] m7GTP has a high affinity for eukaryotic initiation factor eIF4E[4] and may be used to create affinity media for their capture and purification.[6]

General description

7-Methylguanosine 5′-triphosphate is a mRNA cap structural analog.[4]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
0000509568
0000509567
0000509567
0000509568
0000436747

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Ya-Jun Wang et al.
PloS one, 7(9), e44079-e44079 (2012-09-08)
Influenza virus, which spreads around the world in seasonal epidemics and leads to large numbers of deaths every year, has several ribonucleoproteins in the central core of the viral particle. These viral ribonucleoproteins can specifically bind the conserved 3' and
A multifunctional RNA recognition motif in poly (A)-specific ribonuclease with cap and poly (A) binding properties
Nilsson P, et al.
The Journal of biological chemistry, 282(45), 32902-32911 (2007)
Alan L Ho et al.
PloS one, 7(7), e40439-e40439 (2012-07-19)
Uveal melanomas possess activation of the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT/mammalian Target of Rapamycin (mTOR) pathways. MAPK activation occurs via somatic mutations in the heterotrimeric G protein subunits GNAQ and GNA11 for over 70% of tumors and
The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA
Soto-Rifo R, et al.
Nucleic Acids Research, 41(12), 6286-6299 (2013)
Susan Parrish et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(7), 2139-2144 (2007-02-07)
Previous studies indicated that the vaccinia virus D10 protein, which is conserved in all sequenced poxviruses, participates in the rapid turnover of host and viral mRNAs. D10 contains a motif present in the family of Nudix/MutT enzymes, a subset of
Ver todos los artículos relacionados

Questions

Reviews

No rating value

Active Filters

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico