Merck
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P186

Sigma-Aldrich

PD 123,319 di(trifluoroacetate) salt hydrate

powder, ≥98% (HPLC)

Synonym(s):
S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate
Empirical Formula (Hill Notation):
C31H32N4O3 · 2C2HF3O2 · xH2O
CAS Number:
Molecular Weight:
736.66 (anhydrous basis)
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.32

ensayo

≥98% (HPLC)

formulario

powder

condiciones de almacenamiento

desiccated

solubilidad

H2O: 10 mg/mL, clear

temp. de almacenamiento

2-8°C

SMILES string

O.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CN(C)c1ccc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C(c4ccccc4)c5ccccc5)cc1C

InChI

1S/C31H32N4O3.2C2HF3O2.H2O/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;2*3-2(4,5)1(6)7;/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);2*(H,6,7);1H2/t28-;;;/m0.../s1

InChI key

PTSUEYBWHKDYBS-FPCIESGBSA-N

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Aplicación

PD123,319 di (trifluoroacetate) salt hydrate has been used in following experimental studies:
  • To determine the effect of Angiotensin II (Ang II) on alveolar fluid clearance (AFC).[1]
  • To study the effect of PD123319 on AngII-induced abdominal aortic aneurysms (AAAs).[2]
  • To study its effect on Ang II-induced LRP1 overexpression and function in vascular smooth muscle cells (VSMCs) culture.[3]

Envase

10 mg in poly bottle

Acciones bioquímicas o fisiológicas

PD123,319 di (trifluoroacetate) salt hydrate is a widely used angiotensin II subtype-2 receptor (AT2R) antagonist to study the role of AT2 receptor in vitro and in vivo. It increases the AngII-induced abdominal aortic aneurysms (AAAs) without interacting with AT2 receptor.[2]

Precaución

Hygroscopic

Información legal

Sold with permission of Warner-Lambert Company.

pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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