L-Aspartic acid is soluble in water at 5 mg/mL.
A7219
L-Aspartic acid
from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Synonym(s):
(S)-(+)-Aminosuccinic acid, (S)-Aminobutanedioic acid
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About This Item
Linear Formula:
HO2CCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
133.10
NACRES:
NA.75
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-291-6
MDL number:
Beilstein/REAXYS Number:
1723530
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Product Name
L-Aspartic acid, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%
InChI key
CKLJMWTZIZZHCS-REOHCLBHSA-N
InChI
1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
SMILES string
N[C@@H](CC(O)=O)C(O)=O
biological source
non-animal source
agency
meets EP testing specifications
meets USP testing specifications
assay
98.5-101.0%
form
powder
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
color
white to off-white
mp
>300 °C (dec.) (lit.)
solubility
1 M HCl: 100 mg/mL
Quality Level
Gene Information
human ... CA1(759), CA2(760)
rat ... Grin2a(24409)
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This Item | 11189 | A5474 | PHR1104 |
|---|---|---|---|
| form powder | form powder or crystals | form crystalline powder | form - |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) cell culture | mammalian: suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable |
| assay 98.5-101.0% | assay ≥99.5% (T) | assay ≥98.5% | assay - |
| impurities endotoxin, tested | impurities insoluble matter, passes filter test, ≤0.3% foreign amino acids | impurities endotoxin, heavy metals, trace metals, residual solvents, tested | impurities - |
| solubility 1 M HCl: 100 mg/mL | solubility 1 M HCl: 0.5 M at 20 °C, clear, colorless | solubility 1 M HCl: 50 mg/mL | solubility - |
| Quality Level 300 | Quality Level 200 | Quality Level 400 | Quality Level 300 |
Application
L-Aspartic acid has been used:
- as an aspartame (ASP) metabolite to determine acetylcholinesterase (AChE) activity in the hippocampal homogenate of suckling rats[1]
- as printed chemotaxis ligands to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR) and nuclear magnetic resonance (NMR)[2]
- as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) for supplementation assays of various cultured cell lines[3]
Biochem/physiol Actions
Principal neurotransmitter for fast synaptic excitation.
General description
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Aspartic acid
Johnson EC
reference module in biomedical sciences (2017)
Amino acid production
Eggeling L and Sahm H
Comprehensive Biotechnology (2011)
Christopher J Day et al.
Methods in molecular biology (Clifton, N.J.), 1512, 51-63 (2016-11-26)
Despite many years of research into bacterial chemotaxis, the only well characterized system to date is that of E. coli. Even for E. coli, the direct ligand binding had been fully characterized only for aspartate and serene receptors Tar and
Hongyu Ding et al.
Science advances, 7(47), eabk1023-eabk1023 (2021-11-18)
[Figure: see text].
Van T Luu et al.
Bio-protocol, 10(17), e3739-e3739 (2021-03-05)
Genetic transformation is crucial for both investigating gene functions and for engineering of crops to introduce new traits. Rice (Oryza sativa L.) is an important model in plant research, since it is the staple food for more than half of
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