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Merck

67028

Methylglyoxal solution

technical, ~40% in H2O

Synonym(s):

Acetylformaldehyde, Pyruvaldehyde, Pyruvic aldehyde

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About This Item

Linear Formula:
CH3COCHO
CAS Number:
78-98-8
Molecular Weight:
72.06
Beilstein:
906750
MDL number:
MFCD00006960
UNSPSC Code:
12352100
PubChem Substance ID:
329760261
NACRES:
NA.22

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grade

technical

Quality Level

200

concentration

~40% in H2O

density

1.19 g/mL at 20 °C

functional group

aldehyde
ketone

storage temp.

2-8°C

SMILES string

[H]C(=O)C(C)=O

InChI

1S/C3H4O2/c1-3(5)2-4/h2H,1H3

InChI key

AIJULSRZWUXGPQ-UHFFFAOYSA-N

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1 of 4

This Item
M0252W296902G5882
Methylglyoxal solution technical, ~40% in H2O

Sigma-Aldrich

67028

Methylglyoxal solution

Methylglyoxal solution ~40% in H2O

Sigma-Aldrich

M0252

Methylglyoxal solution

Pyruvaldehyde solution 40 wt. % in H2O

Sigma-Aldrich

W296902

Pyruvaldehyde solution

Glutaraldehyde solution Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative

Sigma-Aldrich

G5882

Glutaraldehyde solution

Quality Level

200

Quality Level

200

Quality Level

400

Quality Level

300

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

density

1.19 g/mL at 20 °C

density

1.17 g/mL at 25 °C (lit.)

density

1.178 g/mL at 25 °C

density

-

grade

technical

grade

-

grade

-

grade

-

concentration

~40% in H2O

concentration

~40% (enzymatic), ~40% in H2O

concentration

40 wt. % in H2O

concentration

25% in H2O

functional group

aldehyde

functional group

-

functional group

-

functional group

-

General description

Methylglyoxal is a toxic endogenous by-product of glycolysis.[1] It is a reactive dicarbonyl compound that promotes non-enzymatic glycation of proteins to yield irreversible advanced glycated end products, leading to the cross-linking or degradation of proteins.[2]

Application

Methylglyoxal solution is used in cytotoxic studies.[1][3][2]

Signal Word

Danger

Hazard Statements

H290,H317,H318,H341

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7445V
WXBF5825V
WXBF4922V
WXBF4459V
WXBF3145V

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Potential Neuroprotective and Anti-Apoptotic Properties of a Long-Lasting Stable Analog of Ghrelin: an In Vitro Study Using SH-SY5Y Cells.
Popelova A, et al.
Physiological Research, 67(2), 339-346 (2018)
Determination of methylglyoxal in human blood plasma using fluorescence high performance liquid chromatography after derivatization with 1, 2-diamino-4, 5-methylenedioxybenzene.
Ogasawara Y, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1029, 102-105 (2016)
Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase?I inhibitors.
Al?Balas Q A, et al.
Drug Development Research, 79(2), 58-69 (2018)
Naila Ahmed et al.
Investigative ophthalmology & visual science, 44(12), 5287-5292 (2003-11-26)
To determine the concentrations of methylglyoxal-derived advanced glycation end-products (AGEs), the hydroimidazolones MG-H1 and -H2, in soluble human lens proteins and compare them with the concentrations of other methylglyoxal-derived AGEs and pentosidine. Lens protein samples were hydrolyzed enzymatically. AGEs were
Nicole Schupp et al.
Annals of the New York Academy of Sciences, 1043, 685-695 (2005-07-23)
In patients with chronic renal failure, cancer incidence is increased. This may be related to an elevated level of genomic damage, which has been demonstrated by micronuclei formation as well as by comet assay analysis. Advanced glycation end products (AGEs)
View All Related Papers

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