Fluorescein dilaurate

Name: Fluorescein dilaurate
Brand: SIGMA

suitable for fluorescence, ≥97.0% (HPCE)

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About This Item

Empirical Formula (Hill Notation):

C₄₄H₅₆O₇

CAS Number:

7308-90-9

Molecular Weight:

696.91

UNSPSC Code:

12352106

NACRES:

NA.32

PubChem Substance ID:

57650888

EC Number:

230-764-2

Beilstein/REAXYS Number:

6034843

MDL number:

MFCD00038409

Key Documents

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Product Name

Fluorescein dilaurate, suitable for fluorescence, ≥97.0% (HPCE)

InChI key

MYTRGBGGRICZGN-UHFFFAOYSA-N

InChI

1S/C44H56O7/c1-3-5-7-9-11-13-15-17-19-25-41(45)48-33-27-29-37-39(31-33)50-40-32-34(49-42(46)26-20-18-16-14-12-10-8-6-4-2)28-30-38(40)44(37)36-24-22-21-23-35(36)43(47)51-44/h21-24,27-32H,3-20,25-26H2,1-2H3

SMILES string

CCCCCCCCCCCC(=O)Oc1ccc2c(Oc3cc(OC(=O)CCCCCCCCCCC)ccc3C24OC(=O)c5ccccc45)c1

assay

≥97.0% (HPCE)

form

powder

solubility

ethanol: soluble

fluorescence

λ_ex 490 nm; λ_em 514 nm in 0.1 M Tris pH 8.0 (esterase)

suitability

suitable for fluorescence

Quality Level

100

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Show Differences

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This Item	88596	46935	86826
Sigma-Aldrich 46943 Fluorescein dilaurate	Sigma-Aldrich 88596 Fluorescein-O′-acetic acid	Sigma-Aldrich 46935 6-[Fluorescein-5(6)-carboxamido]hexanoic acid	Sigma-Aldrich 86826 5-Carboxyfluorescein
suitability suitable for fluorescence	suitability suitable for fluorescence	suitability suitable for fluorescence	suitability suitable for fluorescence
fluorescence λ_ex 490 nm; λ_em 514 nm in 0.1 M Tris pH 8.0 (esterase)	fluorescence λ_ex 455 nm; λ_em 514 nm in 0.1 M Tris pH 8.0	fluorescence λ_ex 491 nm; λ_em 515 nm in 0.1 M Tris pH 9.0	fluorescence λ_ex 492 nm; λ_em 517 nm in 0.1 M Tris pH 8.0
form powder	form powder	form solid	form powder
solubility ethanol: soluble	solubility -	solubility DMF: soluble, DMSO: soluble	solubility DMF: soluble, DMSO: soluble, H₂O: soluble
assay ≥97.0% (HPCE)	assay ≥90% (HPCE)	assay ≥90% (HPCE)	assay ≥95% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100

Application

Fluorescein dilaurate is suitable as fluorogenic substrate for esterases/lipases and used in the pancreolauryl test for chronic pancreatitis.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Impaired pancreatic function in patients with Crohn's disease with and without pancreatic autoantibodies.

F Seibold et al.

Journal of clinical gastroenterology, 22(3), 202-206 (1996-04-01)

Pancreatic autoantibodies (PABs) are found in 31% of patients with Crohn's disease (CD), but they do not correlate with the activity of intestinal disease or the incidence of acute pancreatitis. Exocrine pancreatic insufficiency has been observed in patients with CD.

[Effect of various methods of resection of the stomach in liberation of cholecystokinin, neurotensin and on pancreatic function].

M Fuchs et al.

Zentralblatt fur Chirurgie, 120(6), 472-477 (1995-01-01)

In a follow up study 19 patients after Billroth-I, 22 patients after Billroth-II-resection and 38 patients after total gastrectomy (23 with Roux-Y-reconstruction and 15 with Longmire-Gütgemann) underwent a stool fat determination and an indirect pancreatic function test with fluorescein dilaurate

Review article: Pancreatic function testing.

R S Chowdhury et al.

Alimentary pharmacology & therapeutics, 17(6), 733-750 (2003-03-19)

Pancreatic function tests are most commonly used to diagnose chronic pancreatitis. These tests include tests which document exocrine or endocrine gland insufficiency and tests which instead measure gradations of decreased secretory capacity. The tests in the former category generally become

Retrospective audit of the value of the pancreolauryl test in a district general hospital.

I A Murray et al.

Postgraduate medical journal, 79(934), 471-473 (2003-09-05)

To audit the specificity and value of the pancreolauryl test (PLT) for the diagnosis of pancreatic insufficiency. A retrospective case note review of 47 patients who had a PLT during three consecutive years. A 650 bedded district general hospital. Patient

Is the fluorescein dilaurate test suitable for monitoring the effectiveness of pancreatic enzyme replacement therapy?

L M Burrell et al.

Scandinavian journal of clinical and laboratory investigation, 51(8), 675-680 (1991-12-01)

We have employed an oral test of pancreatic digestive function using fluorescein dilaurate (a substrate for pancreatic cholesterol ester hydrolase), administered together with pancreatic enzyme supplements, in order to test the hypothesis that urinary excretion of fluorescein provides a simple

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