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  • In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.

In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy (2006-12-21)
Poonpilas Hongmanee, Kamolchanok Rukseree, Benjamas Buabut, Boontiwa Somsri, Prasit Palittapongarnpim
PMID17178795
ABSTRACT

The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/ml. The MIC(50) and MIC(90) were 0.125 and 0.25 microg/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates.

MATERIALS
Product Number
Brand
Product Description
36524
Supelco
8-Quinolinol, PESTANAL®, analytical standard
Pricing and availability is not currently available.
32502
Sigma-Aldrich
8-Quinolinol, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99% (perchloric acid titration)
Pricing and availability is not currently available.
24880
Sigma-Aldrich
5-Chloro-7-iodo-8-quinolinol, ≥95.0% (HPLC)
Pricing and availability is not currently available.
252565
Sigma-Aldrich
8-Hydroxyquinoline, ACS reagent, 98.5%
Pricing and availability is not currently available.
H6878
Sigma-Aldrich
8-Hydroxyquinoline
Pricing and availability is not currently available.
C47000
Sigma-Aldrich
5-Chloro-8-quinolinol, 95%
Pricing and availability is not currently available.