860062P

Brain SM

Avanti Research^™ - A Croda Brand

• Synonim(y): 18:0 SM; Octadecanoyl Sphingomyelin; N-octadecanoyl-D-erythro-sphingosylphosphorylcholine; N-(octadecanoyl)-sphing-4-enine-1-phosphocholine
• Numer CAS: 383907-91-3
• MDL number: MFCD02259130
• UNSPSC Code: 12352211
• NACRES: NA.25

Właściwości

• Nazwa produktu: Brain SM, Avanti Research^™ - A Croda Brand
• SMILES string: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)COP([O-])(OCC[N+](C)(C)C)=O
• InChI: 1S/C41H83N2O6P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-41(45)42-39(38-49-50(46,47)48-37-36-43(3,4)5)40(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h32,34,39-40,44H,6-31,33,35-38H2,1-5H3,(H-,42,45,46,47)/b34-32+/t39-,40+/m0/s1
• InChI key: LKQLRGMMMAHREN-YJFXYUILSA-N
• description: Sphingomyelin (Brain, Porcine)
• assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 g (860062P-1g); pkg of 1 × 200 mg (860062P-200mg); pkg of 1 × 25 mg (860062P-25mg); pkg of 1 × 500 mg (860062P-500mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• lipid type: sphingolipids
• shipped in: dry ice
• storage temp.: −20°C

Opis

Application

Brain SM is suitable:

• as a standard for high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS)[1]
• as a supplement for cell vacuolation of Hela cells[2]
• for preparation of liposomes[3]

General description

As a major constituent of cell membranes, sphingomyelin is found at particularly high concentrations in the membranes of nerve cells (in the myelin sheaths) and red blood cells. It was previously thought to have a purely structural role, similar to the function of phosphatidylcholine, through intermolecular interactions mediated by the 2-amide group, the 3-hydroxy group and the 4,5-trans double bond of the sphingoid base.[4] However, it is now appreciated that sphingomyelin has a high affinity for cholesterol and that these two lipids pack tightly into liquid-ordered domains among a liquid-disordered phase to form lipid rafts.[4] These membrane microdomains are thought to function as signaling platforms that regulate the localization and interactions of proteins. But sphingomyelin does not just influence signaling as a component of lipid rafts — it is also a precursor to ceramides and other sphingolipid metabolites that comprise the sphingomyelin cycle or sphingolipid network.[4]
Sphingomyelin and related lipids

Packaging

20 mL Clear Glass Screw Cap Vial (860062P-500mg)

5 mL Amber Glass Screw Cap Vial (860062P-200mg)

5 mL Amber Glass Screw Cap Vial (860062P-25mg)

60 mL Amber Wide Mouth Screw Cap Glass Bottle (860062P-1g)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids