1.37162

D(-)-Mannitol

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• Synonim(y): D-Mannitol, Mannite
• Wzór liniowy: HOCH₂(CHOH)₄CH₂OH
• Numer CAS: 69-65-8
• Masa cząsteczkowa: 182.17
• UNSPSC Code: 12352201
• Beilstein/REAXYS Number: 1721898
• MDL number: MFCD00064287

Właściwości

• Quality Segment: 500
• agency: BP, ChP, JP, Ph. Eur., USP
• product line: EMPROVE^® EXPERT
• form: solid
• autoignition temp.: 410 °C
• impurities: low in endotoxins
• pH: 5.0-6.5 (120 °C, 182 g/L)
• bp: 290-295 °C/4.67 hPa
• mp: 166-169 °C, 167-170 °C (lit.)
• solubility: 213 g/L
• application(s): biomolecule formulation; liquid formulation; ophthalmics; parenterals; pharma/biopharma processes; semi-solid formulation; solid formulation
• storage temp.: 2-25°C
• SMILES string: OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
• InChI: 1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
• InChI key: FBPFZTCFMRRESA-KVTDHHQDSA-N

Opis

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins. As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Mannitol is a sugar alcohol which is used widely in biomolecule formulations as a stabilizer, bulking agent, and lyoprotecting agent, especially in lyophilization. Due to its low microbial and endotoxin limits, D(-)-Mannitol Emprove^® Expert is especially suitable for high-risk applications.

Biochem/physiol Actions

A sugar alcohol sweet tastant. Used in sweetness inhibition studies.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable