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351801

Glucose Transporter Inhibitor III, STF-31

Name: Glucose Transporter Inhibitor III, STF-31
Brand: MM
Price: 688 PLN
Availability: InStock

The Glucose Transporter Inhibitor III, STF-31 controls the biological activity of Glucose Transporter.

Synonim(y):

Glucose Transporter Inhibitor III, STF-31, STF-31

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Rozmiar/SKU	Dostępność	Cena netto
10 mg	Przewidywana wysyłka DZISIAJzKuehne + Nagel Sp. z o.o.	688,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₂₃H₂₅N₃O₃S

Masa cząsteczkowa:

423.53

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD04153828

Assay:

≥99% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

688,00 zł

Przewidywana wysyłka DZISIAJSzczegóły

Pomoc techniczna

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Właściwości

Quality Segment

100

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

wet ice

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NCc2ccc(cc2)C(=O)Nc3cnccc3)c1ccc(cc1)C(C)(C)C

InChI key

NGQPRVWTFNBUHA-UHFFFAOYSA-N

Opis

General description

A cell-permeable sulfonamide that selectively inhibits the growth of VHL-deficient renal cell carcinomas (RCCs) dose-dependently (0-5 µM) by directly targeting glucose transporter 1 (GLUT1), which is up-regulated by HIF (hypoxia-inducible factor) transcription factor in VHL-deficient cells. It elicits decreased oxidative phosphorylation associated with aerobic glycolysis and leads to necrosis, which is consistent with the effect induced by GLUT1 RNA interference. It does not bind to other glucose transporters, and does not inhibit a broad range of 50 tested kinases.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chan, D., et al. 2011. Sci. Transl. Med.3, 94ra70.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Ta pozycja	SML1348	189497	SML0409
Sigma-Aldrich 351801 Glucose Transporter Inhibitor III, STF-31	Sigma-Aldrich SML1348 STF-118804	Sigma-Aldrich 189497 Induktor autofagii, STF-62247	Sigma-Aldrich SML0409 STF-083010
description The Glucose Transporter Inhibitor III, STF-31 controls the biological activity of Glucose Transporter.	description ≥98% (HPLC)	description A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL-deficient, but not VHL-expressing, renal carcinoma cells both in vitro and in mice in vivo.	description ≥98% (HPLC)
form solid	form powder	form solid	form powder
assay ≥99% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)
manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename Calbiochem^®	manufacturer/tradename -
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
storage condition OK to freeze, protect from light	storage condition -	storage condition protect from light, OK to freeze	storage condition -

Piktogramy

GHS07

Słowo ostrzegawcze

Warning

Kody zagrożeń

H302

Ostrzeżenia

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Klasa składowania

11 - Combustible Solids

Co się dzieje?

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)