4995

Ouabain octahydrate

≥95% (HPLC), solid, Na⁺,K⁺-ATPase inhibitor, Calbiochem^®

• Synonim(y): Ouabain, Octahydrate, Strophanthin G
• Wzór empiryczny (zapis Hilla): C₂₉H₄₄O₁₂ · 8H₂O
• Numer CAS: 11018-89-6
• Masa cząsteczkowa: 728.77
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00149240
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Właściwości

• Nazwa produktu: Ouabain, Octahydrate, Inhibits Na⁺,K⁺-ATPase.
• Quality Segment: 100
• description: RTECS - RN3850000; Merck USA index - 14 6901
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white to off-white
• solubility: hot water: 10 mg/mL, room-temperature water: insoluble
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: O1CC(=CC1=O)[C@@H]2C3(C(C4[C@H]([C@@H](C3)O)C5([C@@H](C[C@@H](CC5(CC4)O)OC6OC(C(C(C6O)O)O)C)O)CO)(CC2)O)C.O.O.O.O.O.O.O.O
• InChI: 1S/C29H44O12.8H2O/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31;;;;;;;;/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3;8*1H2/t13?,15-,16+,17?,18+,19+,21+,22?,23?,24?,25?,26?,27?,28?,29?;;;;;;;;/m0......../s1
• InChI key: TYBARJRCFHUHSN-HMNHGHQSSA-N

Opis

General description

Inhibits Na⁺ and K⁺-dependent ATPases. Has cardiotonic properties.

Inhibits Na⁺,K⁺-ATPase. Exhibits cardiotonic properties. Preferentially enhances radiotoxicity in tumor cells and induces apoptosis by prolonging the irradiation-induced G₂ delay.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Na⁺,K⁺-ATPase

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Verheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
Hasenauer, J., et al. 1993. J. Biol. Chem.268, 3289.
Rakowski, F.F. 1993. J. Gen. Physiol.101, 117.
Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry31, 2025.
Xu, Z.J., et al. 1992. J. Physiol.456, 405.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H300,H331,H373
• Ostrzeżenia: P260 - P264 - P271 - P301 + P310 - P304 + P340 + P311 - P314
• Hazard Classifications: Acute Tox. 1 Oral - Acute Tox. 3 Inhalation - STOT RE 2
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Co się dzieje?: WGK 3