A2504

6-Aminocaproic acid

≥99% (titration), powder

• Synonim(y): ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA
• Wzór liniowy: H₂N(CH₂)₅CO₂H
• Numer CAS: 60-32-2
• Masa cząsteczkowa: 131.17
• UNSPSC Code: 12352202
• NACRES: NA.77
• PubChem Substance ID: 24890662
• EC Number: 200-469-3
• Beilstein/REAXYS Number: 906872
• MDL number: MFCD00008238
• Assay: ≥99% (titration)
• Form: powder

Właściwości

• biological source: synthetic
• Quality Segment: 300
• assay: ≥99% (titration)
• form: powder
• technique(s): cell culture | mammalian: suitable
• color: white
• mp: 207-209 °C (dec.) (lit.)
• solubility: H₂O: 50 mg/mL
• SMILES string: NCCCCCC(O)=O
• InChI: 1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
• InChI key: SLXKOJJOQWFEFD-UHFFFAOYSA-N
• Gene Information: human ... PLAT(5327), PLG(5340) ; rat ... Ppm1a(24666)

Opis

Application

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl₂, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Biochem/physiol Actions

EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo­xy­peptidase, plasmin, and plasminogen activator.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.

Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• flash_point_f: 404.6 - 408.2 °F
• flash_point_c: 207 - 209 °C
• ppe: dust mask type N95 (US), Eyeshields, Gloves