C4382

Carbamoylcholine chloride

≥98% (titration), Non-selective cholinergic agonist, crystalline

• Synonim(y): (2-Hydroxyethyl)trimethylammonium chloride carbamate, Carbachol, Carbamylcholine chloride
• Wzór liniowy: NH₂COOCH₂CH₂N(Cl)(CH₃)₃
• Numer CAS: 51-83-2
• Masa cząsteczkowa: 182.65
• NACRES: NA.77
• PubChem Substance ID: 24277829
• UNSPSC Code: 12352200
• EC Number: 200-127-3
• MDL number: MFCD00012011
• Beilstein/REAXYS Number: 3917459
• Assay: ≥98% (titration)
• Form: crystalline

Właściwości

• Nazwa produktu: Carbamoylcholine chloride, ≥98% (titration), crystalline
• Quality Segment: 100
• assay: ≥98% (titration)
• form: crystalline
• color: white
• mp: 210 °C (dec.) (lit.)
• solubility: H₂O: 1 g/mL, ethanol: 20 mg/mL
• SMILES string: [Cl-].C[N+](C)(C)CCOC(N)=O
• InChI: 1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
• InChI key: AIXAANGOTKPUOY-UHFFFAOYSA-N
• Gene Information: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), CHRNA2(1135) ; mouse ... Chrm1(12669) ; rat ... Chrm1(25229), Chrm2(81645), Chrm3(24260), Chrna2(170945), Chrna3(25101), Chrna4(25590) ;

Opis

Application

Carbamoylcholine chloride has been used:

• to stimulate insulin secretion in transgenic mice
• to induce contraction of undifferentiated and differentiated human adipose-derived stem cells (hASCs)
• to mediate constriction of iris in pupillary light reflex studies in mice

Biochem/physiol Actions

Non-selective cholinergic agonist that is resistant to the action of cholinesterases; inhibits apoptotic death of cultured neurons, and may induce apoptosis in thymocytes.

Carbachol elicits tear fluid secretion by interacting with muscarinic receptors. It is an analog of acetylcholine and an antiglaucoma drug. In ciliary processes, carbachol along with nitric oxide (NO) regulates Na⁺ and K⁺-ATPase activity. It stimulates insulin vesicles transport to the secretory site to increase insulin secretion.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H300
• Ostrzeżenia: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Klasa składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges