E1024

Estradiol

meets USP testing specifications

• Synonim(y): β-Estradiol, 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin
• Wzór empiryczny (zapis Hilla): C₁₈H₂₄O₂
• Numer CAS: 50-28-2
• Masa cząsteczkowa: 272.38
• UNSPSC Code: 12352104
• NACRES: NA.21
• PubChem Substance ID: 24894380
• EC Number: 200-023-8
• Beilstein/REAXYS Number: 1914275
• MDL number: MFCD00003693

Właściwości

• Quality Segment: 200
• agency: USP/NF, meets USP testing specifications
• form: powder
• mp: 176-180 °C (lit.)
• application(s): pharmaceutical (small molecule)
• SMILES string: O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
• InChI key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• Gene Information: human ... ESR1(2099), ESR2(2100), ESRRB(2103), GPER(2852), SERPINA6(866) ; mouse ... Esr1(13982), Esr2(13983), Esrra(26379) ; rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)

Opis

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary.

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS09
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H351,H360Fd,H362,H410,EUH380,EUH430
• Ostrzeżenia: P201 - P202 - P260 - P263 - P273 - P280 - P308 + P313 - P391 - P405 - P501
• Hazard Classifications: Aquatic Chronic 1 - Carc. 2 - ED ENV 1 - ED HH 1 - Lact. - Repr. 1A
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type P2 (EN 143) respirator cartridges