L9919

LY2033298

≥98% (HPLC)

• Synonim(y): 3-Amino-5-chloro-N-cyclopropyl-6-methoxy-4-methyl-thieno[2,3-b]pyridine-2-carboxamide
• Wzór empiryczny (zapis Hilla): C₁₃H₁₄ClN₃O₂S
• Numer CAS: 886047-13-8
• Masa cząsteczkowa: 311.79
• NACRES: NA.77
• PubChem Substance ID: 329817677
• UNSPSC Code: 12352200
• MDL number: MFCD12912423
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Właściwości

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: off-white to tan
• solubility: DMSO: >20 mg/mL
• originator: Eli Lilly
• storage temp.: −20°C
• SMILES string: COc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl
• InChI: 1S/C13H14ClN3O2S/c1-5-7-9(15)10(11(18)16-6-3-4-6)20-13(7)17-12(19-2)8(5)14/h6H,3-4,15H2,1-2H3,(H,16,18)
• InChI key: CTEGQKDJTBWFHW-UHFFFAOYSA-N

Opis

Biochem/physiol Actions

LY2033298 is a positive allosteric modulator of muscarinic M4 receptor.

LY2033298 is a robust allosteric potentiator that is highly selective for the human M4 muscarinic acetylcholine receptor subtype. LY2033298 potentiates ACh-M4 binding, with no effect at M1/3/5 receptors. LY2033298 can also bind to the M ACh receptor, and mediate either positive or negative allosteric effects depending on the ligand used to probe receptor activity.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08
• Słowo ostrzegawcze: Danger
• Kody zagrożeń: H334
• Ostrzeżenia: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable