N149

Nimodipine

≥98% (HPLC), L-type Ca2+ channel antagonist, powder

• Synonim(y): 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
• Wzór empiryczny (zapis Hilla): C₂₁H₂₆N₂O₇
• Numer CAS: 66085-59-4
• Masa cząsteczkowa: 418.44
• NACRES: NA.77
• PubChem Substance ID: 24277858
• UNSPSC Code: 12352200
• EC Number: 266-127-0
• MDL number: MFCD00153848
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• Nazwa produktu: Nimodipine,
• assay: ≥98% (HPLC)
• Quality Segment: 200
• form: powder
• color: off-white to yellow
• solubility: methanol: 62.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: insoluble, H₂O: insoluble
• originator: Bayer
• SMILES string: COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C
• InChI: 1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
• InChI key: UIAGMCDKSXEBJQ-UHFFFAOYSA-N
• Gene Information: human ... ADORA3(140), CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), CACNG1(786), NR3C2(4306) ; rat ... Adora1(29290), Adora2a(25369) ;

Opis

Application

Nimodipine has been used:

• as a L-type calcium channel (LTCC) inhibitor, to evaluate its neuroprotective activity in the vibrosections
• as a standard, in the enantioseparation of chiral drugs by high performance liquid chromatography (HPLC)
• in the pharmacological studies for the measurement of spine voltage escape

Biochem/physiol Actions

Nimodipine is a potent L-type Ca²⁺ channel antagonist.

Nimodipine enhances the survival of dopaminergic substantia nigra neurons.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Disclaimer

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Słowo ostrzegawcze: Warning
• Kody zagrożeń: H302
• Ostrzeżenia: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): dust mask type N95 (US), Eyeshields, Gloves