Prepared solutions are stable up to 2 months when stored at -20℃. Note that frozen stock solutions may have a precipitate upon thawing. Gentle shaking or brief sonication of the solution will typically dissolve the precipitate. Stock solutions are also stable at 2 - 8℃ when protected from light. Please see the link below to review additional information available in the datasheet for P0409, the non-irradiated version of this product:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/407/849/p0409pis.pdf
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P6532
Prostaglandin E2
γ-irradiated, powder, BioXtra, suitable for cell culture
Synonim(y):
(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid, Dinoprostone, PGE2
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| Rozmiar/SKU | Dostępność | Cena netto |
|---|---|---|
1 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1470,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C20H32O5
Numer CAS:
Masa cząsteczkowa:
352.47
NACRES:
NA.77
PubChem Substance ID:
eCl@ss:
42020658
UNSPSC Code:
12352209
EC Number:
206-656-6
MDL number:
Beilstein/REAXYS Number:
4709356
Biological source:
synthetic (organic)
Form:
powder
1470,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócbiological source
synthetic (organic)
Quality Segment
sterility
γ-irradiated
product line
BioXtra
form
powder
potency
0.25-100 ng/mL
technique(s)
cell culture | mammalian: suitable
solubility
ethanol: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
O[C@@H]1CC([C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O
InChI
1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
InChI key
XEYBRNLFEZDVAW-ARSRFYASSA-N
Gene Information
human ... PTGER1(5731), PTGER2(5732), PTGER3(5733), PTGER4(5734), PTGIR(5739)
mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)
Application
For use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.
Prostaglandin E2 has been used to determine its effects on collagen gel contraction mediated by alveolar cell carcinoma cell line A549.
Biochem/physiol Actions
Most biologically active prostaglandin.
Most biologically active prostaglandin. PGE2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE2-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE2 on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.
Physical form
powder -20 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw
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Ta pozycja | |||
|---|---|---|---|
| description γ-irradiated, powder, BioXtra, suitable for cell culture | description synthetic, powder, BioReagent, suitable for cell culture | description ≥93% (HPLC), synthetic | description Involved in vasodilator actions of kinins such as bradykinin. |
| biological source synthetic (organic) | biological source synthetic | biological source synthetic | biological source - |
| product line BioXtra | product line BioReagent | product line - | product line - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) - |
| form powder | form powder | form powder | form solid |
| solubility ethanol: 1 mg/mL | solubility acetone: 10 mg/mL, clear, colorless to faintly yellow | solubility - | solubility ethanol: soluble, methanol: soluble, acetone: soluble, ethyl acetate: soluble |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1B
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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